Myren J, Osnes M, Larsen S, Hansen T, Ness K
Scand J Gastroenterol. 1986 Aug;21(6):733-6. doi: 10.3109/00365528609011109.
Twenty healthy subjects with a mean age of 23.5 years were studied. Identically appearing tablets of 150 mg ranitidine or placebo were given to each subject twice daily for 2 days. After an overnight fast the same dosage of tablets was given 2 h before introduction of two fiberoptic transducers, the tips of which were localized to the mid-portion of the gastric antrum and the upper third of the duodenum. The double-blind crossover study showed in the placebo period a mean duration of the maximal pressure periods (MPP) of 5.5 min in the duodenum and 3.5 min in the antrum of the stomach. The cyclic length (CL) and the cyclic displacement (CD) in the duodenum were 58 min and 67 mm/min, respectively. After ranitidine the duration of the MPP was significantly longer. The CL was also longer in the duodenum, whereas the CD was shortened, indicating a reduction of the wave movements from the stomach antrum to the duodenum in the ranitidine periods.
对20名平均年龄为23.5岁的健康受试者进行了研究。给每位受试者每日两次服用外观相同的150毫克雷尼替丁片剂或安慰剂，持续2天。经过一夜禁食后，在插入两个光纤换能器前2小时给予相同剂量的片剂，换能器尖端分别置于胃窦中部和十二指肠上三分之一处。双盲交叉研究显示，在安慰剂期，十二指肠最大压力期（MPP）的平均持续时间为5.5分钟，胃窦为3.5分钟。十二指肠的周期长度（CL）和周期位移（CD）分别为58分钟和67毫米/分钟。服用雷尼替丁后，MPP的持续时间显著延长。十二指肠的CL也更长，而CD缩短，这表明在雷尼替丁治疗期间，从胃窦到十二指肠的波动减少。
