Scheurer U, Varga L, Drack E, Bürki H R, Halter F
Am J Physiol. 1983 Mar;244(3):G261-5. doi: 10.1152/ajpgi.1983.244.3.G261.
Motor effects of cholecystokinin octapeptide (CCK-OP) on rat antrum, pylorus, and duodenum have been studied in vitro under standard conditions. Intraluminal pressure changes were simultaneously measured at the three locations using a perfusion manometric system with a novel intraluminal pressure-sensor device. This device comprised an acrylic cast of the rat gastroduodenal tract containing the perfusion catheters that reached the surface of the cast with their outlets in the antrum, pylorus, and duodenum. A selective and sensitive intraluminal local pressure measurement was achieved with this pressure sensor due to its shape. CCK-OP increased base-line pressure in the antrum, pylorus, and duodenum; frequencies of phasic contractions in the antrum and pylorus; and amplitudes in the duodenum. The peptide also decreased contraction amplitudes in the antrum and pylorus and frequency of phasic contractions in the duodenum. It is concluded that the novel intraluminal pressure sensor is a useful tool for measuring local pressure changes in the gastroduodenal tract of the rat. In this experimental model, effects of CCK-OP on antral, pyloric, and duodenal base-line pressure are comparable with those observed in isolated muscle strips and in the intact organ of humans, dogs, and opossums. A different behavior, however, was observed in the force of antral and frequency of duodenal phasic contractions.
在标准条件下，已对大鼠胃窦、幽门和十二指肠进行了八肽胆囊收缩素（CCK-OP）的运动效应体外研究。使用带有新型腔内压力传感器装置的灌注测压系统，同时测量这三个部位的腔内压力变化。该装置包括大鼠胃十二指肠道的丙烯酸铸型，其中含有灌注导管，导管的出口位于胃窦、幽门和十二指肠的铸型表面。由于其形状，该压力传感器实现了选择性和灵敏的腔内局部压力测量。CCK-OP增加了胃窦、幽门和十二指肠的基线压力；胃窦和幽门的相性收缩频率；以及十二指肠的收缩幅度。该肽还降低了胃窦和幽门的收缩幅度以及十二指肠的相性收缩频率。得出的结论是，新型腔内压力传感器是测量大鼠胃十二指肠道局部压力变化的有用工具。在该实验模型中，CCK-OP对胃窦、幽门和十二指肠基线压力的影响与在分离的肌条以及人类、狗和负鼠的完整器官中观察到的影响相当。然而，在胃窦收缩力和十二指肠相性收缩频率方面观察到了不同的表现。
