Department of Clinical Science, Intervention and Technology, Karolinska Institute and Karolinska University Hospital, Stockholm, Sweden.
Department of Oncology-Pathology, Karolinska Institute and University Hospital, Stockholm, Sweden.
Prostate. 2022 Jun;82(8):911-916. doi: 10.1002/pros.24335. Epub 2022 Mar 16.
Thymidine kinase 1 (TK1) recycles DNA before cell division. We do not know if baseline blood concentrations of TK1 predict death in prostate cancer within 30 years. Our objective is to determine if there is an association between baseline levels of TK1 and future prostate cancer-specific mortality.
With a "proof of concept" approach, we performed a nested case-control study among 1782 individuals screened for prostate cancer between 1988 and 1989. The concentration of TK1 was measured in frozen serum from 330 men, 36 of whom have died of prostate cancer. The primary endpoint was prostate cancer-specific mortality and outcomes after 30 years were analyzed using logistic regression modeling odds ratios (Ors).
The estimated OR (adjusted for age) for dying from prostate cancer among the men who had a TK1 value in the upper tertile was 2.39 (95% confidence interval 1.02-5.63). The corresponding OR, regardless of the cause of death, was 2.81 (1.24-6.34).
High levels of TK1 predicts death in prostate cancer within 30 years of follow-up.
胸腺嘧啶激酶 1（TK1）在细胞分裂前循环利用 DNA。我们尚不清楚基线血液中 TK1 浓度是否可以预测 30 年内的前列腺癌死亡。本研究旨在确定 TK1 的基线水平与未来前列腺癌特异性死亡率之间是否存在关联。
采用“概念验证”方法，我们对 1988 年至 1989 年间筛查前列腺癌的 1782 名个体进行了嵌套病例对照研究。对 330 名男性的冷冻血清中 TK1 浓度进行了测量，其中 36 人死于前列腺癌。主要终点为前列腺癌特异性死亡率，30 年后的结局采用 logistic 回归模型进行分析。
在 TK1 值处于上三分之一的男性中，死于前列腺癌的估计比值比（经年龄调整）为 2.39（95%置信区间 1.02-5.63）。无论死亡原因如何，相应的比值比为 2.81（1.24-6.34）。
高 TK1 水平预示着在 30 年随访期间前列腺癌死亡。
