School of Physical Sciences, University of Chinese Academy of Sciences, Beijing, China.
Max Planck Institute for Intelligent Systems, Stuttgart, Germany.
Soft Matter. 2022 Mar 30;18(13):2597-2610. doi: 10.1039/d1sm01665b.
We formulate a theory of electrostatic interactions in lipid bilayer membranes where both monolayer leaflets contain dissociable moieties that are subject to charge regulation. We specifically investigate the coupling between membrane curvature and charge regulation of a lipid bilayer vesicle using both the linear Debye-Hückel (DH) and the non-linear Poisson-Boltzmann (PB) theory. We find that charge regulation of an otherwise symmetric bilayer membrane can induce charge symmetry breaking, non-linear flexoelectricity and anomalous curvature dependence of free energy. The pH effects investigated go beyond the paradigm of electrostatic renormalization of the mechano-elastic properties of membranes.
我们提出了一种在双层脂膜中静电相互作用的理论，其中两个单层叶都包含可离解的部分，这些部分受到电荷调节的影响。我们特别使用线性 Debye-Hückel（DH）和非线性 Poisson-Boltzmann（PB）理论研究了脂质双分子囊泡的膜曲率与电荷调节之间的耦合。我们发现，对于原本对称的双层膜，电荷调节可以诱导电荷对称性破缺、非线性挠曲电和自由能对曲率的反常依赖性。所研究的 pH 效应超出了静电对膜的力学性质的重整化范例。
