Department of Family Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia.
Department of Medicine, Cardiology Section, Faculty of Medicine, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia.
Niger J Clin Pract. 2022 Mar;25(3):299-303. doi: 10.4103/njcp.njcp_1504_21.
Determine the correlation between cardiovascular risk parameters with serum interleukin-6 (IL-6) and high-sensitivity C-reactive protein (hs-CRP) in acute myocardial infarction (AMI).
Blood samples were obtained from 100 AMI patients (aged 40--60 years) admitted to the intensive care unit of our institution from March 2019 to February 2020, and from 40 age- and BMI-matched healthy adults.
Median IL-6 and hs-CRP levels were significantly higher in the AMI group (P < 0.001), as were fasting plasma glucose, HbA1c, triglycerides, and LDLc, while HDLc was significantly lower. In the AMI group, hs-CRP was significantly correlated with BMI (r = 0.531; P < 0.001) and waist circumference (r = 0.448; P < 0.001). No significant differences in hs-CRP and IL-6 levels were observed between male and female AMI patients (5.90 ± 2.0 vs. 6.80 ± 8.2, P = 0.166; 21.23 ± 8.2 vs. 21.06 ± 8.7, P = 0.948, respectively), although IL-6 levels significantly differed between male and female controls (6.64 ± 3.0 vs. 9.74 ± 4.7, P = 0.017).
IL-6 and hsCRP were significantly higher in the AMI group; however, no correlations with the biochemical parameters were observed. Further research into their involvement in the pathogenesis of AMI is needed.
确定急性心肌梗死（AMI）患者的心血管风险参数与血清白细胞介素-6（IL-6）和高敏 C 反应蛋白（hs-CRP）之间的相关性。
从 2019 年 3 月至 2020 年 2 月我院重症监护病房收治的 100 例 AMI 患者（年龄 40-60 岁）和 40 名年龄和 BMI 匹配的健康成年人中采集血样。
AMI 组的 IL-6 和 hs-CRP 中位数显著升高（P < 0.001），空腹血糖、HbA1c、甘油三酯和 LDLc 也显著升高，而 HDLc 则显著降低。在 AMI 组中，hs-CRP 与 BMI（r = 0.531；P < 0.001）和腰围（r = 0.448；P < 0.001）显著相关。男女 AMI 患者的 hs-CRP 和 IL-6 水平无显著差异（5.90 ± 2.0 与 6.80 ± 8.2，P = 0.166；21.23 ± 8.2 与 21.06 ± 8.7，P = 0.948），尽管男女对照组的 IL-6 水平有显著差异（6.64 ± 3.0 与 9.74 ± 4.7，P = 0.017）。
AMI 组的 IL-6 和 hs-CRP 显著升高；然而，与生化参数无相关性。需要进一步研究它们在 AMI 发病机制中的作用。
