实验性星形诺卡菌感染中巨噬细胞与细胞介导免疫的关系。
Relationship of macrophages to cell-mediated immunity in experimental Nocardia asteroides infection.
作者信息
Sundararaj T, Agarwal S C
出版信息
Infect Immun. 1978 Jun;20(3):685-91. doi: 10.1128/iai.20.3.685-691.1978.
Marked in vivo intracellular killing of Nocardia asteroides occurred in the peritoneal macrophages obtained 72 h after an intraperitoneal challenge with N. asteroides, in guinea pigs either actively immunized with ribonucleic acid protein or passively immunized by immune spleen cell transfer from actively immunized donor guinea pigs. This specific killing of N. asteroides in immune macrophages persisted for at least up to 60 days. Administration of antimacrophage sera before intravenous challenge with N. asteroides in the immune guinea pigs produced an early death of the animals, and the total tissue counts of N. asteroides in the liver, spleen, lungs, and heart remained the same in them as in unimmunized controls.
在用星状诺卡菌进行腹腔攻击72小时后获得的豚鼠腹腔巨噬细胞中，观察到对星状诺卡菌有明显的体内细胞内杀伤作用。这些豚鼠要么用核糖核酸蛋白主动免疫，要么通过从主动免疫的供体豚鼠转移免疫脾细胞进行被动免疫。免疫巨噬细胞中对星状诺卡菌的这种特异性杀伤作用至少持续了60天。在用星状诺卡菌对免疫豚鼠进行静脉攻击之前给予抗巨噬细胞血清，会导致动物早期死亡，并且它们肝脏、脾脏、肺和心脏中星状诺卡菌的总组织计数与未免疫的对照相同。
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