实验性星形诺卡菌感染中的细胞介导免疫
Cell-mediated immunity in experimental Nocardia asteroides infection.
作者信息
Sundararaj T, Agarwal S C
出版信息
Infect Immun. 1977 Feb;15(2):370-5. doi: 10.1128/iai.15.2.370-375.1977.
Abstract
Experimental mycetoma-like lesions developed in guinea pigs after subcutaneous injection of Nocardia asteroides. Although delayed hypersensitivity appeared earlier, increased macrophage migration inhibition and microbicidal activity appeared after 7 weeks. When the lesions healed, high cell-mediated immunity was present. Cell-mediated immunity was transferred to normal recipient guinea pigs from healed donor guinea pigs by spleen cell transfer. Recipient guinea pigs showed marked protection against challenge with N. asteroides.
摘要
在豚鼠皮下注射星形诺卡菌后出现了实验性足菌肿样病变。虽然迟发型超敏反应出现得更早，但巨噬细胞移动抑制增加和杀菌活性在7周后出现。当病变愈合时，存在高细胞介导免疫。通过脾细胞转移，细胞介导免疫从愈合的供体豚鼠转移到正常受体豚鼠。受体豚鼠对星形诺卡菌攻击表现出显著的保护作用。
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