Islam A, Bardhan P K, Islam M R, Rahman M
Trop Geogr Med. 1986 Sep;38(3):221-5.
A randomized double blind controlled clinical trial was conducted on 30 patients with cholera and 18 patients with severe non-cholera diarrhoea, to study the antisecretory effect of acetylsalicylic acid (aspirin). The criteria for selection of patients was a stool output of 4 ml/kg per hour over 6 hours of baseline observation. On inclusion into the study, the groups were comparable in sex, age, body weight, duration of diarrhoea and severity of dehydration. Aspirin and placebo (starch) were given by mouth in doses of 25 mg/kg/day for 24 hours in four equally divided doses. Fourteen patients with cholera and 10 with non-cholera diarrhoea received aspirin and the others received placebo. The aspirin and the placebo groups did not differ in their rate of stool output. The results suggest that aspirin in the above mentioned dose has no antisecretory activity.
对30例霍乱患者和18例严重非霍乱性腹泻患者进行了一项随机双盲对照临床试验，以研究乙酰水杨酸（阿司匹林）的抗分泌作用。入选患者的标准是在基线观察的6小时内每小时粪便排出量为4毫升/千克。纳入研究时，各研究组在性别、年龄、体重、腹泻持续时间和脱水严重程度方面具有可比性。阿司匹林和安慰剂（淀粉）以25毫克/千克/天的剂量口服，分4等份，共服用24小时。14例霍乱患者和10例非霍乱性腹泻患者接受了阿司匹林治疗，其余患者接受安慰剂治疗。阿司匹林组和安慰剂组的粪便排出率没有差异。结果表明，上述剂量的阿司匹林没有抗分泌活性。
