Di Bella Stefano, Luzzati Roberto, Principe Luigi, Zerbato Verena, Meroni Elisa, Giuffrè Mauro, Crocè Lory Saveria, Merlo Marco, Perotto Maria, Dolso Elisabetta, Maurel Cristina, Lovecchio Antonio, Dal Bo Eugenia, Lagatolla Cristina, Marini Bruna, Ippodrino Rudy, Sanson Gianfranco
Clinical Department of Medical, Surgical and Health Sciences, University of Trieste, 34127 Trieste, Italy.
Clinical Pathology and Microbiology Unit, "S. Giovanni di Dio" Hospital, 88900 Crotone, Italy.
Biomedicines. 2022 Jan 25;10(2):263. doi: 10.3390/biomedicines10020263.
Acetylsalicylic acid (ASA) is one of the most commonly used drugs in the world. It derives from the extract of white willow bark, whose therapeutic potential was known in Egypt since 1534 BC. ASA's pharmacological effects are historically considered secondary to its anti-inflammatory, platelet-inhibiting properties; however, human studies demonstrating a pro-inflammatory effect of ASA exist. It is likely that we are aware of only part of ASA's mechanisms of action; moreover, the clinical effect is largely dependent on dosages. During the past few decades, evidence of the anti-infective properties of ASA has emerged. We performed a review of such research in order to provide a comprehensive overview of ASA and viral, bacterial, fungal and parasitic infections, as well as ASA's antibiofilm properties.
乙酰水杨酸（ASA）是世界上最常用的药物之一。它源自白柳树皮提取物，其治疗潜力自公元前1534年起在埃及就已为人所知。ASA的药理作用在历史上被认为是其次要的抗炎、抑制血小板特性；然而，也有人类研究表明ASA具有促炎作用。我们可能只了解ASA作用机制的一部分；此外，临床效果在很大程度上取决于剂量。在过去几十年中，已出现了ASA抗感染特性的证据。我们对这类研究进行了综述，以便全面概述ASA与病毒、细菌、真菌和寄生虫感染的关系，以及ASA的抗生物膜特性。
