Yoon Haesung, Kim Jisoo, Lim Hyun Ji, Kamiyama Naohisa, Oguri Takuma, Koh Hong, Lee Mi-Jung
Department of Radiology, Research Institute of Radiological Science, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea; Severance Pediatric Liver Disease Research Group, Severance Children's Hospital, Yonsei University College of Medicine, Seoul, Korea.
Ultrasound General Imaging, GE Healthcare, Hino, Tokyo, Japan.
Ultrasound Med Biol. 2022 Jun;48(6):1070-1077. doi: 10.1016/j.ultrasmedbio.2022.02.005. Epub 2022 Mar 14.
We evaluated the measurement feasibility and diagnostic ability of an ultrasound-guided attenuation parameter (UGAP) using a high-frequency convex transducer in children. This retrospective study included all consecutive children who underwent abdomen ultrasonography from July to December 2020. Attenuation coefficients (ACs) of the liver were measured using both 1- to 6-MHz (AC1-6) and 2- to 9-MHz (AC2-9) probes of the LOGIQ E10 system (GE Healthcare). t-Tests and Pearson's or partial correlation analyses were performed, and AC cutoff values for diagnosing fatty liver were obtained from receiver operating characteristic curve analyses. Finally, 118 patients (M:F = 83:35, mean age: 10.2 ± 4.1 y) were evaluated, and the measurement success rate was 98.3% (116/118) for AC2-9. AC1-6 was available in children with a liver depth greater than 9 cm. The ratio of interquartile range to median of the AC2-9 was lower than that of the AC1-6 (4.3 vs. 8.5, p < 0.001). In the normal group (n = 41), the AC2-9 values were not associated with age, sex or body mass index. For the evaluation of steatosis, the AC2-9 values exhibited a positive correlation with the MR fat fraction (coefficient = 0.498, p < 0.001). The cutoff value of 0.699 dB/cm/MHz had 90.2% sensitivity and 100% specificity for diagnosing fatty liver. In conclusion, measurements of ACs using a high-frequency convex transducer are feasible even in small children, with lower measurement variability. The AC2-9 values also had good diagnostic performance for pediatric fatty liver.
我们评估了使用高频凸阵探头的超声引导衰减参数（UGAP）在儿童中的测量可行性和诊断能力。这项回顾性研究纳入了2020年7月至12月期间所有连续接受腹部超声检查的儿童。使用LOGIQ E10系统（GE医疗集团）的1至6兆赫（AC1-6）和2至9兆赫（AC2-9）探头测量肝脏的衰减系数（AC）。进行了t检验以及Pearson或偏相关分析，并通过受试者操作特征曲线分析获得诊断脂肪肝的AC临界值。最后，评估了118例患者（男∶女 = 83∶35，平均年龄：10.2±4.1岁），AC2-9的测量成功率为98.3%（116/118）。AC1-6适用于肝脏深度大于9厘米的儿童。AC2-9的四分位数间距与中位数之比低于AC1-6（4.3对8.5，p<0.001）。在正常组（n = 41）中AC2-9值与年龄、性别或体重指数无关。对于脂肪变性的评估，AC2-9值与磁共振脂肪分数呈正相关（系数 = 0.498，p<0.叭）。0.699分贝/厘米/兆赫的临界值诊断脂肪肝的灵敏度为90.2%，特异性为100%。总之，即使在幼儿中，使用高频凸阵探头测量AC也是可行的，测量变异性较低。AC2-9值对儿童脂肪肝也具有良好的诊断性能。
