Saigano Keisuke, Inuzuka Yusuke, Fukuie Tatsuki, Kaneko Naoki, Sakai Tomomi, Aoki Yuji, Nakamura Masashi, Matsunaga Kayoko, Ishiguro Akira, Ohya Yukihiro
Allergy Center, National Center for Child Health and Development.
Center for Postgraduate Education and Training, National Center for Child Health and Development.
Arerugi. 2022;71(2):135-139. doi: 10.15036/arerugi.71.135.
Lysozyme chloride is a bactericidal substance that is included as an active ingredient in many medicines and quasi-drugs. We experienced a case of anaphylactic reaction caused by deodorant spray-containing lysozyme chloride.
The patient was a 10-year-old girl who had an egg allergy. She visited an emergency department because of urticaria, wheezing, dyspnea, and pallor after she used deodorant spray that contained lysozyme chloride derived from hen's egg white. Results for deodorant spray and lysozyme chloride were positive in both skin prick tests and basophil activation tests. According to the medical history and the results, her condition was diagnosed as an anaphylactic reaction to lysozyme chloride in the deodorant spray.
Although ingredient labelling is obligatory for lysozyme chloride in quasi-drugs, lysozyme chloride is not often described to be derived from egg white. It is important to alert patients with egg allergy to avoid lysozyme chloride-containing products.
氯化溶菌酶是一种杀菌物质，在许多药品和准药品中作为活性成分使用。我们遇到了一例由含氯化溶菌酶的除臭喷雾引起的过敏反应病例。
患者为一名10岁对鸡蛋过敏的女孩。她在使用了含有来源于鸡蛋白的氯化溶菌酶的除臭喷雾后，因出现荨麻疹、喘息、呼吸困难和面色苍白而前往急诊科就诊。在皮肤点刺试验和嗜碱性粒细胞活化试验中，除臭喷雾和氯化溶菌酶的检测结果均为阳性。根据病史和检测结果，她的病情被诊断为对除臭喷雾中的氯化溶菌酶过敏反应。
虽然准药品中氯化溶菌酶必须进行成分标注，但氯化溶菌酶通常不会被描述为来源于蛋清。提醒对鸡蛋过敏的患者避免使用含氯化溶菌酶的产品很重要。
