Service de Pneumologie et Allergologie Pédiatriques, AP-HP, Hôpital Universitaire Necker-Enfants Malades, Paris, France.
Laboratoire d'Immunologie, Hôpital Necker-Enfants Malades, AP-HP, Paris, France.
Arch Pediatr. 2024 Apr;31(3):209-211. doi: 10.1016/j.arcped.2023.12.005. Epub 2024 Mar 26.
We report an unusual case of anaphylaxis induced by the lysozyme-containing over-the-counter-drug Lysopaine®, which contains 20 mg lysozyme hydrochloride and 1.5 mg cetylpyridinium chloride, in a 9-year-old child with allergy to hen's egg as well as multiple IgE-mediated food allergies. The involvement of lysozyme was confirmed by positive skin prick tests for Lysopaine® and the presence of specific IgE against lysozyme. Our case highlights the importance of properly educating allergic patients to recognize allergens, even minor ones. Despite the presence of lysozyme in various food and drug products, it is not necessarily perceived as an allergenic protein by patients with egg allergy, and the labeling may be misleading, thereby exposing patients to potentially severe reactions.
我们报告了一例由含有溶菌酶的非处方药物 Lysopaine®引起的过敏反应，该药物含有 20 毫克溶菌酶盐酸盐和 1.5 毫克十六烷基吡啶氯化物，患者为 9 岁儿童，对鸡蛋以及多种 IgE 介导的食物过敏。溶菌酶的参与通过 Lysopaine®的皮肤点刺试验阳性和针对溶菌酶的特异性 IgE 证实。我们的病例强调了正确教育过敏患者识别过敏原的重要性，即使是轻微的过敏原也不能忽视。尽管溶菌酶存在于各种食品和药物产品中，但它不一定被鸡蛋过敏患者视为过敏原蛋白，而且标签可能会产生误导，从而使患者面临潜在的严重反应。
