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内侧前额叶皮层和前内侧丘脑的相互作用调节目标导向行为和多巴胺能神经元活动。

Medial prefrontal cortex and anteromedial thalamus interaction regulates goal-directed behavior and dopaminergic neuron activity.

机构信息

Neurocircuitry of Motivation Section, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, 21224, USA.

Department of Neurosurgery, Tangdu Hospital, Fourth Military Medical University, No.1, Xinsi Road, 710038, Xi'an, Shaanxi, P. R. China.

出版信息

Nat Commun. 2022 Mar 16;13(1):1386. doi: 10.1038/s41467-022-28892-7.

DOI:10.1038/s41467-022-28892-7
PMID:35296648
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8927595/
Abstract

The prefrontal cortex is involved in goal-directed behavior. Here, we investigate circuits of the PFC regulating motivation, reinforcement, and its relationship to dopamine neuron activity. Stimulation of medial PFC (mPFC) neurons in mice activated many downstream regions, as shown by fMRI. Axonal terminal stimulation of mPFC neurons in downstream regions, including the anteromedial thalamic nucleus (AM), reinforced behavior and activated midbrain dopaminergic neurons. The stimulation of AM neurons projecting to the mPFC also reinforced behavior and activated dopamine neurons, and mPFC and AM showed a positive-feedback loop organization. We also found using fMRI in human participants watching reinforcing video clips that there is reciprocal excitatory functional connectivity, as well as co-activation of the two regions. Our results suggest that this cortico-thalamic loop regulates motivation, reinforcement, and dopaminergic neuron activity.

摘要

前额叶皮层参与目标导向行为。在这里，我们研究调节动机、强化及其与多巴胺神经元活动关系的前额叶皮层回路。通过 fMRI 显示，刺激小鼠的内侧前额叶皮层 (mPFC) 神经元会激活许多下游区域。刺激下游区域（包括前内侧丘脑核 (AM)）的 mPFC 神经元的轴突末梢会强化行为并激活中脑多巴胺神经元。投射到 mPFC 的 AM 神经元的刺激也会强化行为并激活多巴胺神经元，并且 mPFC 和 AM 显示出正反馈回路组织。我们还通过 fMRI 观察人类参与者观看强化视频剪辑发现，存在相互兴奋的功能连接，以及两个区域的共同激活。我们的研究结果表明，这个皮质-丘脑回路调节动机、强化和多巴胺神经元活动。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce9f/8927595/32c12cae8ed1/41467_2022_28892_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce9f/8927595/8fb3a6afb2e9/41467_2022_28892_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce9f/8927595/91fd2c26506e/41467_2022_28892_Fig2_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce9f/8927595/3430d38b95aa/41467_2022_28892_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce9f/8927595/22935371a319/41467_2022_28892_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce9f/8927595/bb0f638293dc/41467_2022_28892_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce9f/8927595/76d4c9732582/41467_2022_28892_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce9f/8927595/cc694149f64e/41467_2022_28892_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce9f/8927595/32c12cae8ed1/41467_2022_28892_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce9f/8927595/8fb3a6afb2e9/41467_2022_28892_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce9f/8927595/91fd2c26506e/41467_2022_28892_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce9f/8927595/a42ff2c8bb5c/41467_2022_28892_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce9f/8927595/3430d38b95aa/41467_2022_28892_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce9f/8927595/22935371a319/41467_2022_28892_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce9f/8927595/bb0f638293dc/41467_2022_28892_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce9f/8927595/76d4c9732582/41467_2022_28892_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce9f/8927595/cc694149f64e/41467_2022_28892_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce9f/8927595/32c12cae8ed1/41467_2022_28892_Fig9_HTML.jpg

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