Li Y, Zhou Q, Luo X, Li H, Feng Y, Zhao Y, Yang X, Wu Y, Han M, Qie R, Wu X, Zhang Y, Huang S, Li T, Yuan L, Zhang J, Hu H, Liu D, Hu F, Zhang M, Hu D
Dongsheng Hu, Department of Endocrinology, The Affiliated Luohu Hospital of Shenzhen University Health Science Center, 47 Youyi Road, Luohu District, Shenzhen, Guangdong, PR China, E-mail:
J Nutr Health Aging. 2022;26(3):236-242. doi: 10.1007/s12603-022-1727-6.
This study aims to prospectively explore the association between sedentary time and the risk of all-cause mortality in adults based on a cohort from rural areas of China.
The study population included 20,194 adults at baseline (2007-2008) who participated in the Rural Chinese Cohort Study. Cox's proportional hazard regression model was used to analyze the hazard ratios (HRs) and 95% confidence intervals (CIs) of sedentary time and all-cause mortality, and a restricted cubic spline was used to model the dose-response relation. We also carried out a series of sensitivity analyses to verify the robustness of our main results.
The median follow-up duration was 6 years, with a total of 17,265 participants (response rate 85.5%) followed up, and 1,106 deaths observed. Data for 17,048 participants were analyzed, with the mean age of participants being 52.00. Compared with sedentary time <4 h/day group, the risk of all-cause mortality was significantly increased in the 8-11 h/day (HR=1.27, 95%CI:1.03-1.56) and ≥11 h/day groups (HR=1.48, 95%CI:1.20-1.84). With increases in sedentary time, the risk of all-cause mortality increased gradually (Ptrend <0.001). For each 1 h/day increase in sedentary time, the risk of all-cause mortality increased by 3% (HR=1.03, 95%CI: 1.01-1.05). Sensitivity analyses showed our main results were consistent.
Prolonged sedentary time increases the risk of all-cause mortality in the adult rural Chinese population. Reducing sedentary time may have important implications for reducing mortality risk.
本研究旨在基于中国农村地区的队列，前瞻性地探讨成年人久坐时间与全因死亡率风险之间的关联。
研究人群包括2007 - 2008年基线时参与中国农村队列研究的20194名成年人。采用Cox比例风险回归模型分析久坐时间与全因死亡率的风险比（HR）和95%置信区间（CI），并使用受限立方样条来模拟剂量反应关系。我们还进行了一系列敏感性分析以验证主要结果的稳健性。
中位随访时间为6年，共有17265名参与者（应答率85.5%）接受随访，观察到1106例死亡。对17048名参与者的数据进行了分析，参与者的平均年龄为52.00岁。与每天久坐时间<4小时组相比，每天久坐8 - 11小时组（HR = 1.27，95%CI：1.03 - 1.56）和≥11小时组（HR = 1.48，95%CI：1.20 - 1.84）的全因死亡率风险显著增加。随着久坐时间的增加，全因死亡率风险逐渐增加（P趋势<0.001）。久坐时间每增加1小时/天，全因死亡率风险增加3%（HR = 1.03，95%CI：1.01 - 1.05）。敏感性分析表明我们的主要结果是一致的。
久坐时间延长会增加中国农村成年人群的全因死亡率风险。减少久坐时间可能对降低死亡风险具有重要意义。
