From the Departments of Orthopedic and Neurologic Surgery, NYU Langone Orthopedic Hospital; New York Spine Institute, New York, New York (Ahmad, Fernandez, Krol, Kummer, Passfall, Naessig, Pierce, Treitakov, Moattari, Joujon-Roche, Williamson, Imbo, and Passias), the Department of Orthopedics, University of Virginia School of Medicine, Charlottesville, VA (Bell and Hassanzadeh), the Department of Orthopedics, UT Southwestern Medical Center, Dallas, TX (Vira), the Department of Orthopedics, Hospital for Special Surgery, New York, New York (Lafage), the Department of Orthopedics, SUNY Downstate Medical Center, Brooklyn, New, York (Paulino and Diebo), and the Department of Orthopedics, Harvard Medical School, Boston, MA (Schoenfeld).
J Am Acad Orthop Surg. 2022 Apr 15;30(8):e683-e689. doi: 10.5435/JAAOS-D-21-00850.
There is paucity on the effect of different cardiac diagnoses on outcomes in elective spine fusion patients.
Patients undergoing elective spine fusion surgery were isolated in the PearlDiver database. Patients were stratified by having a previous history of coronary artery disease (CAD), congestive heart failure (CHF), valve disorder (valve), dysrhythmia, and no heart disease (control). Means comparison tests (chi-squared and independent samples t-tests, as appropriate) compared differences in demographics, diagnoses, comorbidities, procedural characteristics, length of stay, complication outcomes, and total hospital charges among the cohort.
In total, 537,252 elective spine fusion patients were stratified into five groups: CAD, CHF, valve, dysrhythmia, and control. Among the cohort, patients with CHF had significantly higher rates of morbid obesity, peripheral vascular disease, and chronic kidney disease (P < 0.001 for all). Patients with CAD had significantly higher rates of chronic obstructive pulmonary disease, diabetes, hypertension, and hyperlipidemia (all P < 0.001). Comparing postoperative outcomes for CAD and control subjects, CAD was associated with higher odds of myocardial infarction (odds ratio [OR]: 1.64 [1.27 to 2.11]) (P < 0.05). Assessing postoperative outcomes for CHF versus control subjects, patients with CHF had higher rates of pneumonia, cerebrovascular accident (CVA), myocardial infarction, sepsis, and death (P < 0.001). Compared with control subjects, CHF was a significant predictor of death in spine fusion patients (OR: 2.0 [1.1 to 3.5], P = 0.022). Patients with valve disorder compared with control displayed significantly higher rates of 30-day readmission (P < 0.05) and 1.38× greater odds of CVA by 90 days postoperatively (OR: 1.4 [1.1 to 1.7], P = 0.007). Patients with dysrhythmia were associated with significantly higher odds of CVA (OR: 1.8 [1.4 to 2.3], P < 0.001) by 30 days postoperatively.
Heart disease presents an additional challenge to spine fusion patients who are undergoing a challenging and risky procedure. Before surgical intervention, a proper understanding of cardiac diagnoses could give insight into the potential risks for each patient based on their heart condition and preventive measures showing benefit in minimizing perioperative complications after elective spine fusion.
关于不同心脏诊断对择期脊柱融合患者结局的影响,相关研究较少。
研究人员在 PearlDiver 数据库中筛选出择期脊柱融合手术患者。根据患者是否有冠心病(CAD)、充血性心力衰竭(CHF)、瓣膜疾病(valve)、心律失常以及无心脏病(control),将患者分层。采用均值比较检验(卡方检验和独立样本 t 检验,视情况而定)比较了队列中患者的人口统计学、诊断、合并症、手术特点、住院时间、并发症结局和总住院费用的差异。
共筛选出 537252 例择期脊柱融合患者,分为 CAD、CHF、valve、dysrhythmia 和 control 五组。在该队列中,CHF 患者的病态肥胖、外周血管疾病和慢性肾脏病的发生率显著更高(均 P < 0.001)。CAD 患者的慢性阻塞性肺疾病、糖尿病、高血压和高脂血症的发生率显著更高(均 P < 0.001)。与 CAD 和 control 患者的术后结局相比,CAD 患者发生心肌梗死的几率更高(比值比 [OR]:1.64 [1.27 至 2.11])(P < 0.05)。与 control 患者相比,CHF 患者发生肺炎、中风(CVA)、心肌梗死、败血症和死亡的几率更高(均 P < 0.001)。与 control 患者相比,CHF 是脊柱融合患者死亡的显著预测因素(OR:2.0 [1.1 至 3.5],P = 0.022)。与 control 患者相比,瓣膜疾病患者 30 天内再入院的几率显著更高(P < 0.05),术后 90 天发生中风的几率也显著更高(OR:1.4 [1.1 至 1.7],P = 0.007)。心律失常患者发生中风的几率也显著更高(OR:1.8 [1.4 至 2.3],P < 0.001)。
心脏病给接受具有挑战性和高风险手术的脊柱融合患者带来了额外的挑战。在进行手术干预之前,对心脏诊断的正确理解可以根据患者的心脏状况和预防措施,了解每位患者的潜在风险,这些措施有利于最小化择期脊柱融合术后的围手术期并发症。