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Acta Chim Slov. 2022 Mar 15;69(1):116-124. doi: 10.17344/acsi.2021.7055.
A simple and eco-friendly nano Fe2O3 heterogeneous catalytic system is described for the synthesis of acyl thiourea derivatives from corresponding in situ generated acyl isothiocyanates and amino acid esters in acetone obtained in good yields. The structures of synthesized acyl thioureas were confimed by 1H NMR, 13C NMR, mass, and FTIR analysis. Fe2O3 NPs has been prepared via a solution combustion route using ascorbic acid as the reducing agent and ferric nitrate as the source of iron. The prepared nano material has been characterized by XRD, SEM, UV-Visible, and FTIR analysis. More prominently, the Fe2O3 and other impurities are removed though a simple work-up and the material prepared shows to be effective in catalyzing the conversion of reactants to products in good yields. Further, some of the synthesized acyl thioureas were evaluated for in vitro antibacterial activity against Staphylococcus aureus and Escherichia coli.
一种简单且环保的纳米 Fe2O3 多相催化体系，用于从相应的原位生成的酰基异硫氰酸酯和在丙酮中获得的氨基酸酯合成酰基硫脲衍生物，产率良好。通过 1H NMR、13C NMR、质谱和 FTIR 分析确认了合成的酰基硫脲的结构。Fe2O3 NPs 通过使用抗坏血酸作为还原剂和硝酸铁作为铁源的溶液燃烧法制备。通过 XRD、SEM、UV-可见和 FTIR 分析对制备的纳米材料进行了表征。更值得注意的是，通过简单的后处理除去了 Fe2O3 和其他杂质，并且所制备的材料表现出有效地催化反应物转化为产物，产率良好。此外，一些合成的酰基硫脲被评估了对金黄色葡萄球菌和大肠杆菌的体外抗菌活性。
