Department of Cornea and Anterior Segment, Eye Life, Mumbai, Maharashtra, India.
Ophthalmic Pathology Laboratory, LV Prasad Eye Institute, Hyderabad, Telangana, India.
J Interferon Cytokine Res. 2022 Mar;42(3):137-139. doi: 10.1089/jir.2021.0191.
We describe a rare case of a 58-year-old female with ocular surface squamous neoplasia (OSSN) in her left eye. She was treated for 12 months with topical interferon alpha-2b (IFNα-2b) eye drops and OSSN resolved completely. She presented with a whitish elevated lesion involving the cornea, limbus, and conjunctival surface after discontinuation of topical IFNα-2b. Excision biopsy along with amniotic membrane grafting was done to stabilize the ocular surface. Histopathological evaluation of the excised tissue revealed ocular surface inflammation with no evidence of malignancy.
我们描述了一例左眼眼表面鳞状上皮瘤（OSSN）的 58 岁女性罕见病例。她接受了 12 个月的局部干扰素 alpha-2b（IFNα-2b）滴眼治疗，OSSN 完全消退。停用局部 IFNα-2b 后，她出现了累及角膜、角膜缘和结膜表面的白色隆起性病变。为稳定眼表面，进行了切除活检和羊膜移植。切除组织的组织病理学评估显示眼表面炎症，无恶性证据。
