Radi M J, Fenoglio-Preiser C M, Bartow S A, Key C R, Pathak D R
Am J Gastroenterol. 1986 Sep;81(9):747-56.
Seventeen patients 40 yr of age and less with gastric carcinoma were studied retrospectively. Clinicopathological findings and survival data were collected on all patients. Immunohistochemistry for serotonin, gastrin, somatostatin, carcinoembryonic antigen, beta-human chorionic gonadotropin, and alpha-fetoprotein was performed and the results correlated with pathological and survival data. Patients were divided into two groups according to the presence or absence of endocrine markers in their tumors. The group with endocrine immunoreactivity tended to present with less advanced disease and had longer survival than the group without endocrine immunoreactivity (p less than 0.05). Although the number of patients in the study is too small to reach definite conclusions, our results are interesting in light of current knowledge of the pathobiology of gastric carcinoma and have important implications for future investigations.
对17例40岁及以下的胃癌患者进行了回顾性研究。收集了所有患者的临床病理资料和生存数据。对血清素、胃泌素、生长抑素、癌胚抗原、β-人绒毛膜促性腺激素和甲胎蛋白进行了免疫组化检测，并将结果与病理和生存数据进行了关联分析。根据肿瘤中是否存在内分泌标志物将患者分为两组。具有内分泌免疫反应性的组往往疾病进展程度较低，且生存期比无内分泌免疫反应性的组长（p<0.05）。尽管本研究中的患者数量太少，无法得出明确结论，但鉴于目前对胃癌病理生物学的认识，我们的结果很有意义，并且对未来的研究具有重要意义。
