大剂量阿糖胞苷治疗白血病前期疾病：一项白血病协作组研究
High-dose cytosine arabinoside in the treatment of preleukemic disorders: a leukemia intergroup study.
作者信息
Preisler H D, Raza A, Barcos M, Azarnia N, Larson R, Browman G, Walker I, Grunwald H, D'Arrigo P, Stein A
出版信息
Am J Hematol. 1986 Oct;23(2):131-4. doi: 10.1002/ajh.2830230207.
PMID:3529939
Abstract
Fifteen patients with myelodysplastic/myeloproliferative disorders were treated with high-dose cytosine arabinoside therapy. While severe toxicity was produced in every patient, only two of the 15 patients entered complete remission and two achieved partial remission status. The therapeutic responses were confined to patients who had severe myelofibrosis of apparently recent onset.
摘要
15例骨髓增生异常/骨髓增殖性疾病患者接受了大剂量阿糖胞苷治疗。虽然每位患者均出现了严重毒性，但15例患者中只有2例完全缓解，2例达到部分缓解状态。治疗反应仅限于近期明显出现严重骨髓纤维化的患者。
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