Li Qi-Qi, Zhang Hui-Hong, Dai Shi-Xue
The Second School of Clinical Medicine, Southern Medical University, Guangzhou, China.
Department of Gastroenterology, Guangdong Provincial Geriatrics Institute, National Key Clinical Specialty, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Front Pediatr. 2022 Mar 1;10:714054. doi: 10.3389/fped.2022.714054. eCollection 2022.
Very early onset inflammatory bowel disease (VEO-IBD) is characterized by multifactorial chronic recurrent intestinal inflammation. Compared with elderly patients, those with VEO-IBD have a more serious condition, not responsive to conventional treatments, with a poor prognosis. Recent studies found that genetic and immunologic abnormalities are closely related to VEO-IBD. Intestinal immune homeostasis monogenic defects (IIHMDs) are changed through various mechanisms. Recent studies have also revealed that abnormalities in genes and immune molecular mechanisms are closely related to VEO-IBD. IIHMDs change through various mechanisms. Epigenetic factors can mediate the interaction between the environment and genome, and genetic factors and immune molecules may be involved in the pathogenesis of the environment and gut microbiota. These discoveries will provide new directions and ideas for the treatment of VEO-IBD.
极早发型炎症性肠病（VEO-IBD）的特征是多因素导致的慢性复发性肠道炎症。与老年患者相比，VEO-IBD患者病情更严重，对传统治疗无反应，预后较差。最近的研究发现，基因和免疫异常与VEO-IBD密切相关。肠道免疫稳态单基因缺陷（IIHMDs）通过多种机制发生改变。最近的研究还表明，基因和免疫分子机制异常与VEO-IBD密切相关。IIHMDs通过多种机制发生改变。表观遗传因素可介导环境与基因组之间的相互作用，遗传因素和免疫分子可能参与环境和肠道微生物群的发病机制。这些发现将为VEO-IBD的治疗提供新的方向和思路。
