Department of Oncology, The Affiliated Hospital of Qingdao University, Qingdao Cancer Institute, Qingdao, China.
Central Laboratories, Qingdao Municipal Hospital, Qingdao, China.
Front Immunol. 2023 Dec 22;14:1307985. doi: 10.3389/fimmu.2023.1307985. eCollection 2023.
Inflammatory bowel disease (IBD) is a term encompassing a few chronic inflammatory disorders that leads to damage of the intestinal tract. Although much progress has been made in understanding the pathology of IBD, the precise pathogenesis is not completely understood. Circular RNAs (circRNAs) are single-stranded, covalently closed, endogenous molecules in eukaryotes with a variety of biological functions. CircRNAs have been shown to have regulatory effects in many diseases, such as cancer, cardiovascular disease, and neurological disorders. CircRNAs have also been found to play important roles in IBD, and although they are not sufficiently investigated in the context of IBD, a few circRNAs have been identified as potential biomarkers for the diagnosis and prognosis of IBD and as potential therapeutic targets for IBD. Herein, we survey recent progress in understanding the functions and roles of circRNAs in IBD and discuss their potential clinical applications.
炎症性肠病（IBD）是一个术语，包含几种导致肠道损伤的慢性炎症性疾病。尽管在理解 IBD 的病理学方面已经取得了很大进展，但确切的发病机制仍不完全清楚。环状 RNA（circRNA）是真核生物中具有多种生物学功能的单链、共价闭合的内源性分子。circRNA 已被证明在许多疾病中具有调节作用，如癌症、心血管疾病和神经紊乱。circRNA 也被发现在 IBD 中发挥重要作用，尽管它们在 IBD 背景下的研究还不够充分，但已经确定了一些 circRNA 作为 IBD 诊断和预后的潜在生物标志物，以及作为 IBD 潜在治疗靶点。本文综述了近年来对 circRNA 在 IBD 中的功能和作用的理解进展，并讨论了它们的潜在临床应用。
