Mavissakalian M, Michelson L
Am J Psychiatry. 1986 Sep;143(9):1106-12. doi: 10.1176/ajp.143.9.1106.
Sixty-two agoraphobic patient who had completed a controlled study of therapist-assisted in vivo exposure (flooding) and imipramine were assessed 1 month, 6 months, 1 year, and 2 years later. Overall, improvement during treatment was maintained throughout follow-up. At 1 month but not subsequently, imipramine and flooding had significant effects on central measures of agoraphobia. Patients who were marked treatment responders had a favorable clinical course and did not experience secondary depression, unlike patients who had not responded markedly to treatment. These findings suggest that treatments which evoke maximum therapeutic benefit initially are likely to foster long-term maintenance and reduce subsequent depressive sequelae.
对62名广场恐惧症患者进行了评估，这些患者完成了一项关于治疗师辅助的现场暴露（满灌法）和丙咪嗪的对照研究，评估时间分别为1个月、6个月、1年和2年后。总体而言，治疗期间的改善在整个随访过程中得以维持。在1个月时，丙咪嗪和满灌法对广场恐惧症的核心指标有显著影响，但在随后的时间里则没有。与对治疗反应不明显的患者不同，对治疗有明显反应的患者临床病程良好，且未出现继发性抑郁。这些发现表明，最初能带来最大治疗益处的治疗方法可能有助于长期维持，并减少后续的抑郁后遗症。
