Gartini Sara, Bougrini Youssef, Rhazari Meriem, Bourkadi Jamal Eddine
Pneumology Department, Mohammed VI University Hospital, Oujda, Morocco.
Mohammed First University Oujda, Faculty of Medicine and Pharmacy Oujda, Oujda, Morocco.
Ann Med Surg (Lond). 2022 Mar 9;76:103487. doi: 10.1016/j.amsu.2022.103487. eCollection 2022 Apr.
Macrophage activation syndrome (MAS) is a rare but serious entity, sometimes triggered by an infectious agent, in particular by certain viruses or mycobacteria. Forms of tuberculosis complicated by MAS frequently occur in immunocompromised subjects. The disease is often disseminated, severe, and has a poor prognosis.
We report a case of MAS complicating disseminated tuberculosis and revealing HIV in a previously healthy young patient.
DISCUSSION & CONCLUSION: The management of macrophage activation syndrome related to tuberculosis is complex and not codified. On the one hand, the immunosuppressive treatment allows to slow down the macrophage activation syndrome and obtain a correction of cytopenia. On the other hand, there is a risk of aggravating tuberculosis by increasing the patient's immunodepression.
巨噬细胞活化综合征（MAS）是一种罕见但严重的病症，有时由感染因子引发，特别是某些病毒或分枝杆菌。并发MAS的结核病形式常见于免疫功能低下的患者。该疾病常呈播散性，病情严重，预后不良。
我们报告一例MAS并发播散性结核病并在一名既往健康的年轻患者中发现HIV的病例。
与结核病相关的巨噬细胞活化综合征的管理复杂且未形成规范。一方面，免疫抑制治疗可减缓巨噬细胞活化综合征并纠正血细胞减少。另一方面，存在因加重患者免疫抑制而使结核病恶化的风险。
