François B, Clavel M, Trimoreau F, Desachy A, Slaouti P, Gastinne H
Service de Réanimation Polyvalente, CHU Dupuytren, Limoges.
Rev Mal Respir. 1998 Oct;15(5):668-70.
Haemophagocytic syndromes or syndromes involving macrophage activation are rare complications of tuberculosis, whether they be pulmonary or polyvisceral. They are characterised by an anomalous increase in the phagocytic power of macrophages with phagocytosis of the formed elements of blood. The clinical biological picture associates a change in the general physical state accompanied by organomegaly, hyperferritinaemia and pancytopenia. Their occurrence is a poor prognostic factor and few treatment seem to check this mechanism. The authors report a rare case of marked macrophage activation syndrome complicating pulmonary tuberculosis in a patient who was HIV negative without an underlying blood disturbance and a favourable outcome.
噬血细胞综合征或涉及巨噬细胞活化的综合征是结核病的罕见并发症，无论其为肺结核还是多脏器结核。其特征为巨噬细胞吞噬能力异常增强，并伴有吞噬血液有形成分。临床生物学表现为一般身体状况改变，伴有器官肿大、高铁蛋白血症和全血细胞减少。它们的出现是一个不良预后因素，而且似乎很少有治疗方法能抑制这种机制。作者报告了一例罕见的显著巨噬细胞活化综合征并发肺结核的病例，该患者为HIV阴性，无潜在血液疾病，且预后良好。
