Hu Shaonan, Yu Feifan, Jiang Hong, Shang Wei, Miao Hui, Li Simin, Zhao Jianjiang, Xiao Hui
Innovation Center Computer Assisted Surgery, Leipzig University, Leipzig, Germany.
School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA, United States.
Front Cardiovasc Med. 2022 Mar 1;9:830732. doi: 10.3389/fcvm.2022.830732. eCollection 2022.
Periodontal disease has been associated with gestational complications and both conditions have a high prevalence in rural populations from developing regions. A cross-sectional study was carried out to explore the relationship between periodontal inflamed surface area (PISA), blood pressure (BP), and, serum uric acid levels (UA) in a group of rural North Chinese pregnant women in the third trimester of pregnancy.
Three hundred and thirty-five rural women aged 20-34 years, with normal body mass index (BMI) were examined in a cross-sectional study during their third trimester of gestation. Exclusion criteria were history of pregnancy complications, multiple pregnancy, smoking habits, diabetes, hypertension or any known infectious disease. Socio-demographic variables, including age and socioeconomic status (SES), systolic blood pressure (SBP) and diastolic blood pressure (DBP) readings, serum UA levels, and PISA values were recorded. A structural equation model was implemented with two constructed latent variables including "Dem" (comprising of age and SES category to represent unobserved demographic variables) and, "BP" (comprising of SBP and DBP to account for measurement error and lack of multiple BP readings). The model accounted for co-variance of BP and UA, and implemented simultaneous regressions for BP and UA as outcomes, upon Dem and PISA values as exogenous variables.
The median PISA score was 1,081.7 (IQR = 835.01), reflecting high levels of periodontal inflammation in the sample. SEM showed a significant association of PISA with BP (estimate = 0.011, 95% CI = 0.009-0.012 < 0.001) and UA (estimate = 0.001, 95% CI = 0.001-0.001, < 0.001).
Higher PISA values were significantly associated with higher blood pressure and uric acid levels among rural pregnant women in a cross-sectional sample from a center in North China after accounting for a latent demographic construct derived from age and SES.
牙周病与妊娠并发症有关，且这两种情况在发展中地区的农村人口中普遍存在。开展了一项横断面研究，以探讨一组中国北方农村妊娠晚期孕妇的牙周炎症表面积（PISA）、血压（BP）和血清尿酸水平（UA）之间的关系。
在一项横断面研究中，对335名年龄在20 - 34岁、体重指数（BMI）正常的农村妇女在妊娠晚期进行了检查。排除标准包括妊娠并发症史、多胎妊娠、吸烟习惯、糖尿病、高血压或任何已知的传染病。记录社会人口统计学变量，包括年龄和社会经济地位（SES）、收缩压（SBP）和舒张压（DBP）读数、血清UA水平和PISA值。实施了一个结构方程模型，其中包括两个构建的潜在变量，即“Dem”（由年龄和SES类别组成，以代表未观察到的人口统计学变量）和“BP”（由SBP和DBP组成，以考虑测量误差和缺乏多个血压读数）。该模型考虑了BP和UA的协方差，并以Dem和PISA值作为外生变量，对BP和UA作为结果进行了同时回归。
PISA评分中位数为1081.7（IQR = 835.01），反映样本中牙周炎症水平较高。结构方程模型显示PISA与BP（估计值 = 0.011，95%CI = 0.009 - 0.012，< 0.001）和UA（估计值 = 0.001，95%CI = 0.001 - 0.001，< 0.001）有显著关联。
在考虑了由年龄和SES得出的潜在人口统计学结构后，来自中国北方一个中心的横断面样本中，较高的PISA值与农村孕妇较高的血压和尿酸水平显著相关。
