Westermann C J, van Weelden B M, Laros C D
Allergy. 1986 May;41(4):308-10. doi: 10.1111/j.1398-9995.1986.tb02034.x.
Fifteen adult patients with nocturnal asthma entered a double blind study. They received a single evening dose of one sustained-release (SR) terbutaline tablet à 7.5 mg or an identical placebo tablet for 1 week, each in a randomised cross-over fashion in addition to their usual medication. In the 12 evaluated patients there was no change in evening PEF but a significant improvement in morning PEF (P less than 0.05) and in overnight fall of PEF (P less than 0.01) on active treatment. Symptoms were improved by both placebo and active medication. Three patients experienced tremor as a side effect. A single evening dose of SR-terbutaline can be of help in nocturnal asthma.
15名成年夜间哮喘患者进入一项双盲研究。他们除了使用常规药物外，还以随机交叉的方式，每晚服用一片7.5毫克的缓释（SR）特布他林片或一片相同的安慰剂片，为期1周。在12名接受评估的患者中，使用活性药物治疗时，夜间呼气峰流速（PEF）没有变化，但早晨PEF有显著改善（P<0.05），PEF夜间下降幅度也有显著改善（P<0.01）。安慰剂和活性药物均能改善症状。3名患者出现震颤副作用。每晚单次服用SR-特布他林对夜间哮喘可能有帮助。
