Fu Xiaoyu, Tan Wei, Song Qibin, Pei Huadong, Li Juanjuan
Department of Breast and Thyroid Surgery, Renmin Hospital of Wuhan University, Wuhan, China.
Cancer Center, Renmin Hospital of Wuhan University, Wuhan, China.
Front Cell Dev Biol. 2022 Mar 1;10:813457. doi: 10.3389/fcell.2022.813457. eCollection 2022.
Breast cancer susceptibility gene 1 () is a tumor suppressor gene, which is mainly involved in the repair of DNA damage, cell cycle regulation, maintenance of genome stability, and other important physiological processes. Mutations or defects in the gene significantly increase the risk of breast, ovarian, prostate, and other cancers in carriers. In this review, we summarized the molecular functions and regulation of and discussed recent insights into the detection and treatment of mutated breast cancer.
乳腺癌易感基因1（）是一种肿瘤抑制基因，主要参与DNA损伤修复、细胞周期调控、基因组稳定性维持等重要生理过程。该基因的突变或缺陷会显著增加携带者患乳腺癌、卵巢癌、前列腺癌等其他癌症的风险。在这篇综述中，我们总结了该基因的分子功能和调控，并讨论了近年来对该基因突变型乳腺癌检测与治疗的新见解。
