一种来自Roxb.根部的罕见异黄酮醌和一种新黄烷酮。
A rare isoflavone-quinone and a new flavanone from the roots of Roxb.
作者信息
Sribuhom Thurdpong, Posri Priyapan, Khankeaw Wilaiwan, Pornchoo Chanakan, Prawan Auemduan, Tontapha Sarawut, Amornkitbamrung Vittaya, Yenjai Chavi
机构信息
Faculty of Science, Natural Products Research Unit, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Khon Kaen University, Khon Kaen, Thailand.
Faculty of Medicine, Department of Pharmacology, Khon Kaen University, Khon Kaen, Thailand.
出版信息
Nat Prod Res. 2023 Jul-Aug;37(15):2532-2540. doi: 10.1080/14786419.2022.2053852. Epub 2022 Mar 17.
Two previously undescribed compounds, namely dalpulapans F and G ( and ), along with 11 known compounds were isolated from the MeOH crude extract of the roots of . Dalpulapan F was found as a rare isoflavone-quinone derivative. Their structures and absolute configurations were supported by extensive spectroscopic data analysis, including 1 D and 2 D NMR, HRESIMS data, specific rotation data, and comparison of the experimental and calculated ECD data. Cytotoxicity evaluation of the isolated compounds against HepG2 and KKU-M156 cell lines revealed that isoflavonoid and rotenoid exhibited the most activity against the two cell lines.
从[植物名称]根部的甲醇粗提物中分离出两种之前未被描述的化合物，即dalpulapans F和G（[化合物结构简式]），以及11种已知化合物。Dalpulapan F是一种罕见的异黄酮-醌衍生物。通过广泛的光谱数据分析，包括一维和二维核磁共振、高分辨电喷雾电离质谱数据、比旋光度数据以及实验和计算的电子圆二色光谱数据的比较，确定了它们的结构和绝对构型。对分离出的化合物针对HepG2和KKU-M156细胞系的细胞毒性评估显示，异黄酮类化合物[化合物名称]和鱼藤酮类化合物[化合物名称]对这两种细胞系表现出最强的活性。
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