绒毛黄檀根中两种新异黄酮的细胞毒性。
Cytotoxicities of two new isoflavanes from the roots of Dalbergia velutina.
作者信息
Kaennakam Sutin, Siripong Pongpun, Tip-Pyang Santi
机构信息
Natural Products Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand.
Natural Products Research Section, Research Division, National Cancer Institute, Bangkok, 10400, Thailand.
出版信息
J Nat Med. 2017 Jan;71(1):310-314. doi: 10.1007/s11418-016-1039-4. Epub 2016 Sep 7.
Two new isoflavanes, dalvelutinanes A (1) and B (2), along with three known isoflavanes (3-5) were isolated from the roots of Dalbergia velutina. Their chemical structures, including their absolute configurations, were determined by spectroscopic analysis (1D and 2D NMR, HRESIMS, and CD). All isolated compounds were evaluated for their in vitro cytotoxicities against five human cancer cell lines (KB, HeLa-S3, MCF-7, HepG-2, and HT-29). Compound 5 showed significant cytotoxicity against all of the tested cancer cell lines, with IC values in the range 3.47-9.76 µM. In addition, compound 3 showed significant cytotoxicity against the KB and HeLa-S3 cells, with IC values of 8.29 and 9.54 µM, respectively, and compound 2 showed significant cytotoxicity against the MCF-7 cell line, with an IC value of 4.69 µM.
从绒毛黄檀的根部分离出两种新的异黄酮，即绒毛黄檀素A（1）和B（2），以及三种已知的异黄酮（3 - 5）。通过光谱分析（一维和二维核磁共振、高分辨电喷雾电离质谱和圆二色光谱）确定了它们的化学结构，包括它们的绝对构型。对所有分离得到的化合物进行了针对五种人类癌细胞系（KB、HeLa - S3、MCF - 7、HepG - 2和HT - 29）的体外细胞毒性评估。化合物5对所有测试的癌细胞系均表现出显著的细胞毒性，其半数抑制浓度（IC）值在3.47 - 9.76微摩尔范围内。此外，化合物3对KB和HeLa - S3细胞表现出显著的细胞毒性，IC值分别为8.29和9.54微摩尔，化合物2对MCF - 7细胞系表现出显著的细胞毒性，IC值为4.69微摩尔。
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