黄檀木茎中的 Veluflavanones A-P，细胞毒性香叶基化二氢黄酮
Veluflavanones A-P, Cytotoxic Geranylated Flavanones from Dalbergia velutina Stems.
机构信息
Center of Excellence in Natural Products Chemistry, Department of Chemistry, Faculty of Science , Chulalongkorn University , Bangkok , Thailand , 10330.
Natural Products Research Section , National Cancer Institute , Bangkok , Thailand , 10400.
出版信息
J Nat Prod. 2019 Feb 22;82(2):276-282. doi: 10.1021/acs.jnatprod.8b00688. Epub 2019 Feb 5.
Sixteen new geranylated flavanones, named veluflavanones A-P (1-16), and a known analogue (17), were isolated from Dalbergia velutina. The chemical structures of 1-17, as well as their absolute configurations, were determined by spectroscopic analysis and experimental ECD data. All isolated compounds were tested for their cytotoxicity against five human cancer cell lines. Compound 9 showed cytotoxicity toward KB, HeLa S3, and MCF-7 cells with IC values of 9.9, 8.1, and 10.0 μM, respectively. In addition, compounds 10, 11, 14, and 16 exhibited selective cytotoxicity against HeLa S3 cells with IC values of 6.6-9.9 μM.
从黄檀属Velutina 中分离得到十六个新的香叶基黄酮，命名为 veluflavanones A-P（1-16）和一个已知类似物（17）。通过光谱分析和实验 ECD 数据确定了 1-17 的化学结构及其绝对构型。所有分离得到的化合物均进行了对五种人癌细胞系的细胞毒性测试。化合物 9 对 KB、Hela S3 和 MCF-7 细胞的细胞毒性分别为 9.9、8.1 和 10.0 μM。此外，化合物 10、11、14 和 16 对 Hela S3 细胞具有选择性细胞毒性，IC 值为 6.6-9.9 μM。
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