The Key Laboratory of Plant Resources and Chemistry of Arid Zone, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, China; State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, China; University of the Chinese Academy of Sciences, Beijing, 100039, China.
The Key Laboratory of Plant Resources and Chemistry of Arid Zone, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, China; State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, China.
Phytochemistry. 2022 Jul;199:113158. doi: 10.1016/j.phytochem.2022.113158. Epub 2022 Mar 14.
Twelve undescribed sesquiterpene lactones and seven known sesquiterpene lactones were isolated from the whole plant of Artemisia mongolica. Their structures were elucidated based on the interpretation of NMR, HRESIMS, and electronic circular dichroism (ECD) data. The absolute configurations of mongolicolide A (1), mongolicolide C (3), 1R, 3S-Dihydroxy-7S, 11R-germacra-4Z.9Z-dien-12, 6S-olide (5), indicumolide E (9), indicumolide F (10), and indicumolide G (11) were determined by single-crystal X-ray crystallography. The X-ray crystal structure of artabsinolide E (15) was reported for the first time. In addition, beibersteneolide-B (13) showed moderate anti-inflammatory activity and marked antitumor activity, artemyriantholide E (18) show moderate antitumor activity.
从蒙古蒿全草中分离得到 12 个未见文献报道的倍半萜内酯和 7 个已知倍半萜内酯。根据 NMR、HRESIMS 和电子圆二色谱（ECD）数据的解析，确定了它们的结构。通过单晶 X 射线衍射确定了 mongolicolide A（1）、mongolicolide C（3）、1R，3S-二羟基-7S，11R-大根香叶-4Z，9Z-二烯-12，6S-内酯（5）、indicumolide E（9）、indicumolide F（10）和 indicumolide G（11）的绝对构型。首次报道了 artabsinolide E（15）的 X 射线晶体结构。此外，beibersteneolide-B（13）表现出中等的抗炎活性和显著的抗肿瘤活性，artemyriantholide E（18）表现出中等的抗肿瘤活性。
