从山茛菪中提取的土木香内酯型倍半萜内酯及其抗炎活性。
Guaianolide-type sesquiterpene lactones from Achillea millefolium L. and their anti-inflammatory activity.
机构信息
State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, And Key Laboratory of Plant Resources and Chemistry of Arid Zone, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, China; University of Chinese Academy of Sciences, Beijing, 100049, China.
State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, And Key Laboratory of Plant Resources and Chemistry of Arid Zone, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, China; University of Chinese Academy of Sciences, Beijing, 100049, China.
出版信息
Phytochemistry. 2023 Dec;216:113894. doi: 10.1016/j.phytochem.2023.113894. Epub 2023 Oct 14.
Seventeen undescribed guaianolide sesquiterpene lactones, millefoliumines A-Q, and seven known analogues were isolated from the whole plant of Achillea millefolium L. growing in Xinjiang, China. Their structures were elucidated based on the HRESIMS and NMR data analyses. The absolute configurations of millefoliumines A-Q were determined by single-crystal X-ray crystallography, ECD data analysis along with quantum-chemical ECD calculations. The anti-inflammatory effects of these compounds on the LPS-induced RAW264.7 cell model were evaluated. As a result, millefoliumine G exhibited potential inhibitory effects on the release of NO, the level of pro-inflammatory cytokines including TNF-α and IL-6. Above results indicated a potential of the guaianolides from A. millefolium in the anti-inflammatory drug development.
从中国新疆生长的蓍草全草中分离得到了 17 种未描述的愈创木烷型倍半萜内酯，即 milefoliumines A-Q，以及 7 种已知类似物。基于高分辨质谱和 NMR 数据分析阐明了它们的结构。通过单晶 X 射线晶体学、ECD 数据分析以及量子化学 ECD 计算确定了 milefoliumines A-Q 的绝对构型。评估了这些化合物对 LPS 诱导的 RAW264.7 细胞模型的抗炎作用。结果表明，millefoliumine G 对 NO 的释放、TNF-α 和 IL-6 等促炎细胞因子的水平具有潜在的抑制作用。上述结果表明，蓍草中的愈创木烷型倍半萜内酯具有在抗炎药物开发方面的潜力。
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