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[横向牵张成骨术:肢体挽救的新机遇?]

[Transverse distraction osteogenesis : New chances for limb salvage?].

作者信息

Thaller P H, Fürmetz J, Böcker W, Ehrnthaller C

机构信息

3D-Chirurgie, Muskuloskelettales Universitätszentrum München, Klinikum der LMU München, Campus Innenstadt, Ziemssenstr. 5, 80336, München, Deutschland.

Sporttraumatologie und Arthroskopische Chirurgie, BG Unfallklinik Murnau, Murnau, Deutschland.

出版信息

Unfallchirurg. 2022 Apr;125(4):282-287. doi: 10.1007/s00113-022-01156-1. Epub 2022 Mar 17.

Abstract

Distraction osteogenesis (DO) is a technique that can be successfully used to treat leg length discrepancies and to reconstruct long defects of bone. By gradual distraction of the bone fragments by approximately 1 mm per day, hypervascularization and an increased bone healing potential (growth stimulus) occur. So far, DO has almost exclusively been used longitudinally to generate new biologically active bone. Chronic wounds, ulcers and osteitis, especially in the region of the foot, are always a challenge for the treating surgeon, since treatment is tedious, the outcome uncertain and associated with possible loss of the extremity. Transverse distraction osteogenesis (tDO) now uses the growth stimulus of the DO translationally to treat distally located, chronic wounds and thus leads to accelerated wound healing. At the end of the 5‑week treatment, the transversely distracted fragment, located far proximal to the chronic wound, is back in its original location. The biological stimulus has a long-lasting effect, longer than the tDO itself. Further investigations into the mechanisms of action and treatment outcomes of tDO are required. If the previous results are confirmed, tDO may become a game changer and enable the limb salvage for a large proportion of findings that previously required amputation.

摘要

牵张成骨术(DO)是一种可成功用于治疗肢体长度差异和重建长骨缺损的技术。通过每天将骨碎片逐渐牵张约1毫米,会发生血管过度增生和骨愈合潜力增加(生长刺激)。到目前为止,DO几乎仅纵向用于生成新的生物活性骨。慢性伤口、溃疡和骨炎,尤其是足部区域的,对治疗外科医生来说始终是一项挑战,因为治疗过程繁琐,结果不确定且可能伴有肢体丧失。横向牵张成骨术(tDO)现在将DO的生长刺激应用于横向,以治疗远端的慢性伤口,从而加速伤口愈合。在为期5周的治疗结束时,横向牵张的骨碎片位于远离慢性伤口的近端,回到其原始位置。这种生物刺激具有持久的效果,比tDO本身持续时间更长。需要对tDO的作用机制和治疗结果进行进一步研究。如果先前的结果得到证实,tDO可能会成为一个改变局面的因素,并使很大一部分先前需要截肢的病例能够实现保肢。

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