Faculty of Pharmacy, Department of Biochemistry, Agri Ibrahim Cecen University, Agri, Turkey.
Faculty of Pharmacy, Department of Pharmacology, Ataturk University, Erzurum, Turkey.
Mol Biol Rep. 2022 May;49(5):3875-3883. doi: 10.1007/s11033-022-07235-1. Epub 2022 Mar 17.
We aimed to investigate the effects of rasagiline on acute lung injury that develops in the sepsis model induced with the cecal ligation and puncture in rats.
The rats were separated into the following six groups, Group 1: Sham, Group 2: Sham + Rasagiline 4 mg/kg, Group 3: Sepsis, Group 4: Sepsis + Rasagiline 1 mg/kg, Group 5: Sepsis + Rasagiline 2 mg/kg, Group 6: Sepsis + Rasagiline 4 mg/kg. A total of four holes were opened with a 16-gauge needle through the cecum distal to the point of ligation.
Rasagiline treatment increased glutathione level and superoxide dismutase activity while decreased the malondialdehyde level after the sepsis. There was a statistically significant improvement in the doses of 2 mg/kg and 4 mg/kg. Rasagiline also increased Tnf-α, IL1β, IL6, NF-κβand HMGB1 gene expressions in dose-dependent at 2 mg/kg and 4 mg/kg doses. In increased doses, rasagiline prevent the development of edema, the formation of inflammation, and hemorrhage.
Rasagiline exerts both antioxidant and anti-inflammatory effects on the cecal ligation and puncture induced acute lung injury in rats.
我们旨在研究雷沙吉兰对盲肠结扎穿刺诱导的脓毒症大鼠急性肺损伤的影响。
将大鼠分为以下六组：假手术组（Sham）、假手术+雷沙吉兰 4mg/kg 组（Sham+Rasagiline 4mg/kg）、脓毒症组（Sepsis）、脓毒症+雷沙吉兰 1mg/kg 组（Sepsis+Rasagiline 1mg/kg）、脓毒症+雷沙吉兰 2mg/kg 组（Sepsis+Rasagiline 2mg/kg）、脓毒症+雷沙吉兰 4mg/kg 组（Sepsis+Rasagiline 4mg/kg）。通过在结扎点远端的盲肠上用 16 号针开四个孔。
雷沙吉兰治疗可增加谷胱甘肽水平和超氧化物歧化酶活性，同时降低脓毒症后的丙二醛水平。在 2mg/kg 和 4mg/kg 剂量下，有统计学意义的改善。雷沙吉兰还可剂量依赖性地增加 Tnf-α、IL1β、IL6、NF-κβ和 HMGB1 基因表达。在增加的剂量下，雷沙吉兰可预防水肿的发展、炎症的形成和出血。
雷沙吉兰对盲肠结扎穿刺诱导的大鼠急性肺损伤具有抗氧化和抗炎作用。
