Aydın Pelin, Bekmez Hüseyin
Department of Anesthesiology and Reanimation, Erzurum City Hospital, Erzurum, Turkey.
Department of Pharmacology, Atatürk University Faculty of Medicine, Erzurum, Turkey.
Eurasian J Med. 2023 Dec 29;55(1):120-124. doi: 10.5152/eurasianjmed.2023.23364.
Sepsis is a major health problem that causes millions of deaths worldwide every year. Due to the complexity of its pathophysiology, there is no clear treatment method for it. Existing treatments impose an additional financial burden on the health systems of countries every year. Clinical and preclinical studies are continuously being conducted in order to prevent the development of sepsis, treat patients with sepsis, reduce mortality, and solve the socioeconomic problems that arise from it. However, it is not possible to directly test every study and potential new treatment in humans. Preclinical studies enable an understanding of pathophysiological events and the development of targeted therapies. For this purpose, many experimental sepsis models have been and continue to be applied. The extent to which these models can reflect the human sepsis condition is an important issue that needs to be emphasized. Each method has diferent strengths and weaknesses. Researchers should choose the most appropriate experimental model according to the characteristics of the experiments they plan and, if possible, conduct their studies on diferent models.
脓毒症是一个重大的健康问题，每年在全球导致数百万人死亡。由于其病理生理学的复杂性，目前尚无明确的治疗方法。现有的治疗方法每年都给各国的卫生系统带来额外的经济负担。为了预防脓毒症的发展、治疗脓毒症患者、降低死亡率以及解决由此产生的社会经济问题，临床和临床前研究一直在持续进行。然而，不可能直接在人体上测试每一项研究和潜在的新治疗方法。临床前研究有助于了解病理生理事件并开发靶向治疗方法。为此，已经并将继续应用许多实验性脓毒症模型。这些模型能够反映人类脓毒症状况的程度是一个需要强调的重要问题。每种方法都有不同的优缺点。研究人员应根据他们计划开展的实验的特点选择最合适的实验模型，并在可能的情况下在不同的模型上进行研究。
