Danish Headache Center, Department of Neurology, Rigshospitalet- Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.
Danish Headache Knowledge Center, Rigshospitalet - Glostrup, Glostrup, Denmark.
Cephalalgia. 2022 Jul;42(8):781-792. doi: 10.1177/03331024221077665. Epub 2022 Mar 18.
To systematically review clinical studies investigating the involvement of adenosine and its receptors in migraine pathophysiology.
Adenosine is a purinergic signaling molecule, clinically used in cardiac imaging during stress tests. Headache is a frequent adverse event after intravenous adenosine administration. Migraine headache relief is reported after intake of adenosine receptor antagonist, caffeine. These findings suggest a possible involvement of adenosine signaling in migraine pathophysiology and its potential as a drug target.
A search through PubMed and EMBASE was undertaken for clinical studies investigating the role of adenosine and its receptors in migraine, published until September 2021.
A total of 2510 studies were screened by title and abstract. Of these, seven clinical studies were included. The main findings were that adenosine infusion induced headache, and plasma adenosine levels were elevated during ictal compared to interictal periods in migraine patients.
The present systematic review emphasizes a potentially important role of adenosine signaling in migraine pathogenesis. Further randomized and placebo-controlled clinical investigations applying adenosine receptors modulators in migraine patients are needed to further understand the adenosine involvement in migraine.
系统综述腺苷及其受体在偏头痛发病机制中的作用的临床研究。
腺苷是一种嘌呤能信号分子，临床上用于应激试验中的心脏成像。静脉内给予腺苷后常出现头痛等不良反应。偏头痛患者使用腺苷受体拮抗剂咖啡因后可缓解头痛。这些发现提示腺苷信号可能参与偏头痛发病机制，并有作为药物靶点的潜力。
通过 PubMed 和 EMBASE 检索截至 2021 年 9 月发表的关于腺苷及其受体在偏头痛中作用的临床研究。
通过标题和摘要筛选出 2510 项研究。其中纳入 7 项临床研究。主要发现是腺苷输注可诱发头痛，偏头痛患者发作期与间歇期相比，血浆腺苷水平升高。
本系统综述强调了腺苷信号在偏头痛发病机制中可能具有重要作用。需要进一步开展随机、安慰剂对照的临床研究，应用腺苷受体调节剂治疗偏头痛患者，以进一步了解腺苷在偏头痛中的作用。
