Department of Pediatrics, The First Affiliated Hospital of Anhui Medical University, No. 218 Jixi Road, Hefei, 230022, Anhui, China; Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People's Republic of China, No 81 Meishan Road, Hefei, 230032, Anhui, China; NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, No 81 Meishan Road, Hefei, 230032, Anhui, China; Anhui Provincial Key Laboratory of Population Health and Aristogenics, Anhui Medical University, No 81 Meishan Road, Hefei, 230032, Anhui, China.
Anhui Provincial Key Laboratory of Population Health and Aristogenics, Anhui Medical University, No 81 Meishan Road, Hefei, 230032, Anhui, China; Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, No 81 Meishan Road, Hefei, 230032, Anhui, China.
Chemosphere. 2022 Jul;299:134319. doi: 10.1016/j.chemosphere.2022.134319. Epub 2022 Mar 14.
Few studies have investigated the relationships between gestational phthalate exposure and maternal circulating vitamin D. In the Ma'anshan birth cohort, 3265 pregnant women were included. Each woman provided up to three urine and serum samples for measurement of phthalates and 25(OH)D and calcium, respectively. Linear mixed models were performed to analyse the association between phthalate metabolites and 25(OH)D and calcium. Stratified analyses of the relationship between phthalates and 25(OH)D by urine collection season were conducted. Finally, the post hoc lag effect of phthalate exposure on 25(OH)D was determined if longitudinal associations were significant. Some phthalate metabolites were associated with increased 25(OH)D but with decreased calcium. Furthermore, the relationship of phthalate exposure with 25(OH)D varied with urine collection season. Phthalate metabolites collected in summer and autumn were associated with an increase in 25(OH)D, while monobenzyl phthalate collected in winter and spring was inversely associated with 25(OH)D. Finally, high-molecular-weight phthalates had lag associations with 25(OH)D with a 1-trimester lag period. Low-molecular-weight phthalates exhibited lag associations with 25(OH)D with a 2-trimester lag period. In conclusion, the positive cross-sectional correlation between phthalate metabolites and 25(OH)D was partly affected by urine collection season. This study suggested that gestational phthalate exposure would have a lag association with maternal 25(OH)D levels.
鲜有研究调查妊娠时期邻苯二甲酸酯暴露与母体循环维生素 D 之间的关系。在马鞍山出生队列中，纳入了 3265 名孕妇。每位女性提供了多达三份尿液和血清样本，分别用于测量邻苯二甲酸酯代谢物和 25(OH)D 及钙。采用线性混合模型分析了邻苯二甲酸酯代谢物与 25(OH)D 和钙之间的关联。进行了按尿液采集季节分层的分析，以研究邻苯二甲酸酯与 25(OH)D 之间的关系。如果纵向关联有意义，则确定邻苯二甲酸酯暴露对 25(OH)D 的滞后效应。一些邻苯二甲酸酯代谢物与 25(OH)D 增加有关，但与钙减少有关。此外，邻苯二甲酸酯暴露与 25(OH)D 的关系随尿液采集季节而变化。夏季和秋季采集的邻苯二甲酸酯代谢物与 25(OH)D 增加有关，而冬季和春季采集的单苄基邻苯二甲酸酯与 25(OH)D 呈负相关。最后，高分子量邻苯二甲酸酯与 25(OH)D 有滞后关联，滞后期为 1 个孕早期。低分子量邻苯二甲酸酯与 25(OH)D 有滞后关联，滞后期为 2 个孕中期。总之，邻苯二甲酸酯代谢物与 25(OH)D 之间的横断面正相关部分受到尿液采集季节的影响。本研究表明，妊娠时期邻苯二甲酸酯暴露与母体 25(OH)D 水平呈滞后关联。
