Department of Pediatrics, the First Affiliated Hospital of Anhui Medical University, No.218 Jixi Road, Hefei 230022, Anhui, China; Key Laboratory of Population Health Across Life Cycle, Anhui Medical University, Ministry of Education of the People's Republic of China, No. 81 Meishan Road, Hefei 230032, Anhui, China; NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, No. 81 Meishan Road, Hefei 230032, Anhui, China.
Key Laboratory of Population Health Across Life Cycle, Anhui Medical University, Ministry of Education of the People's Republic of China, No. 81 Meishan Road, Hefei 230032, Anhui, China; NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, No. 81 Meishan Road, Hefei 230032, Anhui, China; Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, No. 81 Meishan Road, Hefei 230032, Anhui, China.
Sci Total Environ. 2022 Sep 10;838(Pt 3):156498. doi: 10.1016/j.scitotenv.2022.156498. Epub 2022 Jun 3.
Few studies have investigated the associations between prenatal phthalate exposure and placental structure and function with inconsistent conclusions.
Nested on the Ma'anshan Birth Cohort study, 2723 women provided spot urine samples during the first, second and third trimesters of pregnancy to analyze six phthalate metabolites. The outcomes of interest were placental weight, efficiency (birth weight/placental weight), chorionic disc area and disc eccentricity. The relationships of prenatal exposure to a single phthalate with placental measures were analyzed. The associations between prenatal phthalate mixture exposure and placental measures were also evaluated.
Most phthalate metabolites were significantly associated with placental weight, efficiency and chorionic disc area during the whole gestation and in each trimester of pregnancy, with different directions of relationships. Sensitivity analyses revealed similar findings, indicating the robustness of the statistical results. Furthermore, inverted U-shaped nonlinear relationships of prenatal exposure to some phthalate metabolites with placental weight, efficiency and chorionic plate area were observed. However, quantile g-computation mixture models did not reveal any association between maternal combined exposure to the total phthalate metabolites and placental measures.
Maternal exposure to most phthalates and their metabolites was associated with placental weight, efficiency and chorionic plate area in both a linear manner and an inverted U-shaped nonlinear manner. However, the mixture of multiple phthalate metabolites was not observed to be associated with any placental measure.
很少有研究调查产前邻苯二甲酸酯暴露与胎盘结构和功能之间的关系，且结论不一致。
在马鞍山市出生队列研究中，2723 名女性在妊娠的第一、二、三个月提供了点尿样，以分析 6 种邻苯二甲酸代谢物。感兴趣的结果是胎盘重量、效率（出生体重/胎盘重量）、绒毛膜盘面积和盘偏心度。分析了产前单一邻苯二甲酸暴露与胎盘指标的关系。还评估了产前邻苯二甲酸混合物暴露与胎盘指标的关系。
大多数邻苯二甲酸代谢物与整个妊娠期和妊娠各期的胎盘重量、效率和绒毛膜盘面积呈显著相关，其关系方向不同。敏感性分析得出了类似的发现，表明统计结果具有稳健性。此外，还观察到产前暴露于某些邻苯二甲酸代谢物与胎盘重量、效率和绒毛膜板面积之间呈倒 U 型非线性关系。然而，定量 g 计算混合物模型并未显示母体对总邻苯二甲酸代谢物的综合暴露与胎盘指标之间存在任何关联。
大多数邻苯二甲酸及其代谢物的母体暴露与胎盘重量、效率和绒毛膜板面积呈线性和倒 U 型非线性相关。然而，未观察到多种邻苯二甲酸代谢物的混合物与任何胎盘指标相关。
