七种新的 2-(2-苯乙基)色酮衍生物来自白木香，具有抑制一氧化氮生成的作用。
Seven new 2-(2-phenylethyl) chromone derivatives from agarwood of Aquilaria agallocha with inhibitory effects on nitric oxide production.
机构信息
The MOE Key Laboratory of Standardization of Chinese Medicines, The SATCM Key Laboratory of New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Shanghai Frontiers Science Center of TCM Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicines, Shanghai 201203, China.
The MOE Key Laboratory of Standardization of Chinese Medicines, The SATCM Key Laboratory of New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
出版信息
Fitoterapia. 2022 Jun;159:105177. doi: 10.1016/j.fitote.2022.105177. Epub 2022 Mar 14.
Seven new 2-(2-Phenethyl) chromone derivatives (1-7), including four 2-(2-Phenethyl) chromones (1-4), one 6, 7, 8 trihydroxy-2-(2-Phenethyl) chromone (5), one acetylated 5, 6, 7, 8-tetrahydroxy-2-(2-Phenethyl) chromone (6), and one chlorine-containing 5, 6, 7, 8-tetrahydro-2-(2-Phenethyl) chromone (7), along with eight known compounds (8-15), were isolated from agarwood originating from Aquilaria agallocha Roxb.. Their structures were determined mainly by high-resolution electrospray ionization mass spectrometry (HR-ESI-MS) and nuclear magnetic resonance (NMR) analysis. The absolute configurations of 3-7 were resolved by electronic circular dichroism (ECD) calculations. Nearly all compounds were evaluated for their anti-inflammatory activities in RAW264.7 cells. Compounds 1 and 7-11 displayed significant anti-inflammatory activities with IC values ranging from 3.71 to 32.04 μM.
从沉香Aquilaria agallocha Roxb. 中分离得到 7 个新的 2-(2-苯乙基)色酮衍生物(1-7)，包括 4 个 2-(2-苯乙基)色酮(1-4)、1 个 6,7,8-三羟基-2-(2-苯乙基)色酮(5)、1 个乙酰化 5,6,7,8-四羟基-2-(2-苯乙基)色酮(6)和 1 个含氯 5,6,7,8-四氢-2-(2-苯乙基)色酮(7)，以及 8 个已知化合物(8-15)。它们的结构主要通过高分辨率电喷雾电离质谱(HR-ESI-MS)和核磁共振(NMR)分析确定。通过电子圆二色(ECD)计算解析了 3-7 的绝对构型。几乎所有的化合物都在 RAW264.7 细胞中进行了抗炎活性评估。化合物 1 和 7-11 表现出显著的抗炎活性，IC 值范围为 3.71-32.04 μM。
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