从白木香中分离得到的 7 种新的 2-(2-苯乙基)色酮衍生物。
Seven new 2-(2-phenethyl)chromone derivatives from agarwood of Aquilaria walla.
机构信息
School of Forestry, Hainan University, Haikou 570228, PR China; Hainan Engineering Research Center of Agarwood, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, PR China.
Hainan Engineering Research Center of Agarwood, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, PR China.
出版信息
Fitoterapia. 2023 Mar;165:105421. doi: 10.1016/j.fitote.2022.105421. Epub 2022 Dec 29.
Two rare flavonoid-2-(2-phenylethyl)chromones and five new dimeric 2-(2-phenylethyl)chromones were isolated from ethanol extract of agarwood of Aquilaria walla by LC-MS-guided fractionation procedure. Their structures were established based on extensive spectroscopic methods including HRESIMS, 1D and 2D NMR, as well as by comparison with the literature. Compound 1 showed cytotoxic activity against five human cancer cell lines with IC values ranging from 13.40 to 28.96 μM with cisplatin as the positive control.
通过 LC-MS 引导的分段程序，从沉香属植物 Agarwood 的乙醇提取物中分离得到两种罕见的黄酮-2-(2-苯乙基)色酮和五种新的二聚体 2-(2-苯乙基)色酮。根据广泛的光谱方法，包括 HRESIMS、1D 和 2D NMR，并与文献进行比较，确定了它们的结构。化合物 1 对五种人癌细胞系表现出细胞毒性活性，IC 值范围为 13.40 至 28.96 μM，顺铂为阳性对照。
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