六种前所未有的 2-(2-苯乙基)色酮二聚体来自白木香 Agarwood of Aquilaria filaria。
Six unprecedented 2-(2-phenethyl)chromone dimers from agarwood of Aquilaria filaria.
机构信息
National Key Laboratory for Tropical Crop Breeding, International Joint Research Center of Agarwood, Hainan Engineering Research Center of Agarwood, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, PR China; Hubei Key Laboratory of Natural Product Research and Development (China Three Gorges University), College of Biological and Pharmaceutical Sciences, China Three Gorges University, Yichang 443002, PR China.
National Key Laboratory for Tropical Crop Breeding, International Joint Research Center of Agarwood, Hainan Engineering Research Center of Agarwood, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, PR China.
出版信息
Fitoterapia. 2024 Jun;175:105905. doi: 10.1016/j.fitote.2024.105905. Epub 2024 Mar 11.
Six new dimeric 2-(2-phenylethyl)chromones (1-6) were successfully isolated from the ethanol extract of agarwood of Aquilaria filaria from Philippines under HPLC-MS guidance. Compounds 1-6 are all dimers formed by linking 5,6,7,8-tetrahydro-2-(2-phenylethyl)chromone and flindersia 2-(2-phenylethyl)chromone via a single ether bond, and the linkage site (C5-O-C8'') of compound 2 is extremely rare. A variety of spectroscopic methods were used to ascertain their structures, including extensive 1D and 2D NMR spectroscopic analysis, HRESIMS, and comparison with literature. The in vitro tyrosinase inhibitory and anti-inflammatory activities of each isolate were assessed. Among these compounds, compound 2 had a tyrosinase inhibition effect with an IC value of 27.71 ± 2.60 μM, and compound 4 exhibited moderate inhibition of nitric oxide production in lipopolysaccharide-stimulated RAW264.7 cells with an IC value of 35.40 ± 1.04 μM.
在 HPLC-MS 指导下，从菲律宾沉香木（Aquilaria filaria）的乙醇提取物中成功分离出六种新的二聚体 2-（2-苯乙基）色酮（1-6）。化合物 1-6 均为由 5,6,7,8-四氢-2-（2-苯乙基）色酮和弗氏 2-（2-苯乙基）色酮通过单醚键连接而成的二聚体，并且化合物 2 的连接位点（C5-O-C8''）极为罕见。使用多种光谱方法确定了它们的结构，包括广泛的 1D 和 2D NMR 光谱分析、HRESIMS 以及与文献的比较。评估了每种分离物的体外酪氨酸酶抑制和抗炎活性。在这些化合物中，化合物 2 对酪氨酸酶具有抑制作用，IC 值为 27.71 ± 2.60 μM，化合物 4 对脂多糖刺激的 RAW264.7 细胞中一氧化氮的产生具有中等抑制作用，IC 值为 35.40 ± 1.04 μM。
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