Pal'tsev M A, Iargin S V, Krotovskiĭ G S, Turpitko S A, Mamedov D M
Arkh Patol. 1986;48(6):34-40.
Light-optical, electron microscopic and morphometric studies of biopsy material from kidneys of 24 patients with vasorenal hypertension were performed. It was determined that sclerosis of the arteries and arterioles on the side of the lesion was more marked, than in the contralateral kidney. At a later stage of the disease (more than 3 yr.) there were occasional signs of increased renin-synthesizing activity of the juxtaglomerular apparatus (JGA) with its simultaneous decrease at the stenotic side. JGA activation in the contralateral kidney can be one of the mechanisms supporting hyperrenin arterial hypertension and can prevent the decrease of the blood pressure after surgery. Studying of the biopsy material with the estimation of the sclerosis degree of the arterial tree vessels, as well as JGA activity, is important for prognosing the results of surgical treatment of vasorenal hypertension.
对24例肾血管性高血压患者的肾脏活检材料进行了光学显微镜、电子显微镜和形态计量学研究。结果表明，病变侧的动脉和小动脉硬化比健侧更明显。在疾病后期（超过3年），偶尔会出现肾小球旁器（JGA）肾素合成活性增加的迹象，同时狭窄侧的肾素合成活性降低。对侧肾脏的JGA激活可能是支持高肾素性动脉高血压的机制之一，并且可以防止手术后血压下降。通过评估动脉树血管的硬化程度以及JGA活性来研究活检材料，对于预测肾血管性高血压手术治疗的结果很重要。
