McDonald M B, Kaufman H E, Durrie D S, Keates R H, Sanders D R
Arch Ophthalmol. 1986 Sep;104(9):1294-300. doi: 10.1001/archopht.1986.01050210048024.
The nationwide study of epikeratophakia for the treatment of keratoconus involved 69 surgeons in the United States; they operated on 177 eyes as of Dec 31, 1985. In this first report, the results from 35 surgeons involving 82 cases with 30 or more days of follow-up after suture removal are described. In all but two patients, uncorrected visual acuity improved; 17 patients showed improvement of three Snellen lines, and 38 patients showed improvement of four or more lines. The majority of patients' vision returned to within one line of their best corrected acuity; in 78% it was 20/40 or better postoperatively. Eight patients needed no postoperative overrefraction at all. The mean flattening by keratometry readings was 9.36 diopters, and the mean decrease in myopia in terms of spherical equivalent was 5.26 D. No significant changes in intraocular pressure or endothelial cell counts were noted. Some advantages of epikeratophakia for keratoconus over the traditional penetrating keratoplasty include the lack of serious, vision-threatening complications or permanent vision loss, the reversible nature of the surgery, and the absence of potential immunogenic rejection phenomena.
一项关于角膜表层镜片术治疗圆锥角膜的全国性研究涉及美国69位外科医生;截至1985年12月31日,他们共为177只眼睛实施了手术。在这份首次报告中,描述了35位外科医生的82例患者在拆线后30天或更长时间随访的结果。除两名患者外,所有患者的未矫正视力均有提高;17例患者视力提高了3行Snellen视力表视标,38例患者视力提高了4行或更多行。大多数患者的视力恢复到最佳矫正视力的1行以内;78%的患者术后视力达到20/40或更好。8例患者术后根本不需要追加验光。角膜曲率计测量的平均角膜变平度数为9.36屈光度,等效球镜度计算的近视平均降低度数为5.26 D。未发现眼压或内皮细胞计数有显著变化。与传统穿透性角膜移植术相比,角膜表层镜片术治疗圆锥角膜的一些优点包括没有严重的、威胁视力的并发症或永久性视力丧失、手术具有可逆性以及不存在潜在的免疫原性排斥现象。