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阻塞性睡眠呼吸暂停、糖尿病前期与 2 型糖尿病进展：系统评价和荟萃分析。

Obstructive sleep apnea, prediabetes and progression of type 2 diabetes: A systematic review and meta-analysis.

机构信息

Department of Geriatrics, Tianjin Medical University General Hospital, Tianjin Geriatrics Institute, Tianjin, China.

Tianjin Medical University, Tianjin, China.

出版信息

J Diabetes Investig. 2022 Aug;13(8):1396-1411. doi: 10.1111/jdi.13793. Epub 2022 Apr 14.

DOI:10.1111/jdi.13793
PMID:35302714
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9340883/
Abstract

AIMS/INTRODUCTION: Obstructive sleep apnea (OSA) is related to prediabetes and diabetes. Whether patients with OSA have a higher risk of prediabetes/diabetes remains unclear. We aimed to carry out a meta-analysis of published studies to evaluate the relationships between OSA and prediabetes and diabetes, and the impact of the severity of OSA on diabetes.

MATERIALS AND METHODS

The PubMed, EMBASE and Cochrane databases were searched from January 2011 to July 2021. The associations between OSA and impaired fasting glucose, impaired glucose tolerance, impaired glucose regulation and diabetes mellitus were analyzed. We estimated the pooled odds ratios using fixed or random effects models. We included 25 studies comprising a total of 154,948 patients with OSA and risk factors for prediabetes/diabetes (20 and 16, respectively) in the analysis.

RESULTS

OSA was associated with a higher risk of impaired fasting glucose, impaired glucose tolerance, impaired glucose regulation and diabetes mellitus in the cohort studies and cross-sectional studies. The pooled odds ratios were 2.34 (95% confidence interval [CI] 1.16-4.72), 1.58 (95% CI 1.15-2.15), 1.65 (95% CI 1.12-2.42), 2.15 (95% CI 1.68-2.75) and 3.62 (95% CI 2.75-4.75), respectively. Subgroup analyses were based on the proportions of men and women. The results showed that OSA was a risk factor, and there was no significant difference between the two groups. The risk of diabetes increased with the severity of OSA.

CONCLUSIONS

The risk of developing prediabetes and diabetes was higher in patients with OSA.

摘要

目的/引言：阻塞性睡眠呼吸暂停（OSA）与糖尿病前期和糖尿病有关。患有 OSA 的患者发生糖尿病前期/糖尿病的风险是否更高尚不清楚。我们旨在对已发表的研究进行荟萃分析，以评估 OSA 与糖尿病前期和糖尿病之间的关系，以及 OSA 严重程度对糖尿病的影响。

材料和方法

从 2011 年 1 月至 2021 年 7 月，检索了 PubMed、EMBASE 和 Cochrane 数据库。分析了 OSA 与空腹血糖受损、葡萄糖耐量受损、葡萄糖调节受损和糖尿病之间的关系。我们使用固定或随机效应模型估计了汇总优势比。我们将 25 项研究纳入分析，共纳入了 154948 例患有 OSA 和糖尿病前期/糖尿病危险因素的患者（分别为 20 例和 16 例）。

结果

队列研究和横断面研究显示，OSA 与空腹血糖受损、葡萄糖耐量受损、葡萄糖调节受损和糖尿病的风险增加相关。汇总优势比分别为 2.34（95%置信区间 [CI] 1.16-4.72）、1.58（95% CI 1.15-2.15）、1.65（95% CI 1.12-2.42）、2.15（95% CI 1.68-2.75）和 3.62（95% CI 2.75-4.75）。亚组分析基于男性和女性的比例。结果表明，OSA 是一个危险因素，两组之间没有显著差异。随着 OSA 严重程度的增加，糖尿病的风险增加。

结论

患有 OSA 的患者发生糖尿病前期和糖尿病的风险更高。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57d1/9340883/42e946f72770/JDI-13-1396-g001.jpg
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