间歇性低氧作为阻塞性睡眠呼吸暂停的模型：现状与未来。
Intermittent Hypoxia as a Model of Obstructive Sleep Apnea: Present and Future.
作者信息
Badran Mohammad, Gozal David
机构信息
Department of Pediatrics, University of Missouri, 7 Hospital Drive, Medical Science Building, Room MA104C, Columbia, MO 65202, USA; Department of Medical Physiology and Pharmacology, University of Missouri, Columbia, MO, USA.
Office of the Dean and Department of Pediatrics, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 25701, USA.
出版信息
Sleep Med Clin. 2025 Mar;20(1):93-102. doi: 10.1016/j.jsmc.2024.10.009. Epub 2024 Nov 16.
Abstract
Intermittent hypoxia (IH) is an extremely frequent condition characterized by recurrent episodes of reduced oxygen levels interspersed with periods of normoxia, often seen in conditions like obstructive sleep apnea (OSA) and lung diseases. Among OSA patients, IH occurs due to periodic airway obstructions during sleep, leading to transient drops in blood oxygen saturation followed by reoxygenation. Future directions involve standardizing IH protocols, incorporating patient variability into the IH profiles being administered, and utilizing strategically developed animal models to enhance the reliability and applicability of IH-related research.
摘要
间歇性低氧（IH）是一种极为常见的情况，其特征为反复出现的氧水平降低发作，并穿插着常氧期，常见于阻塞性睡眠呼吸暂停（OSA）和肺部疾病等病症。在OSA患者中，IH是由于睡眠期间周期性气道阻塞导致的，从而引起血氧饱和度短暂下降，随后再氧合。未来的方向包括规范IH方案，将患者个体差异纳入所实施的IH模式中，并利用精心开发的动物模型来提高IH相关研究的可靠性和适用性。
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