转化生长因子-β1 在调节性 T 细胞生物学中的作用。
Transforming growth factor-β1 in regulatory T cell biology.
机构信息
Department of Dermatology, University of California, San Francisco, San Francisco, CA, USA.
Pelotonia Institute for Immuno-Oncology, the Ohio State University Comprehensive Cancer Center-James Cancer Hospital, Columbus, OH, USA.
出版信息
Sci Immunol. 2022 Mar 18;7(69):eabi4613. doi: 10.1126/sciimmunol.abi4613.
Abstract
Transforming growth factor-β1 (TGF-β1) is inextricably linked to regulatory T cell (T) biology. However, precisely untangling the role for TGF-β1 in T differentiation and function is complicated by the pleiotropic and context-dependent activity of this cytokine and the multifaceted biology of T. Among CD4 T cells, T are the major producers of latent TGF-β1 and are uniquely able to activate this cytokine via expression of cell surface docking receptor glycoprotein A repetitions predominant (GARP) and αv integrins. Although a preponderance of evidence indicates no essential roles for T-derived TGF-β1 in T immunosuppression, TGF-β1 signaling is crucial for T development in the thymus and periphery. Furthermore, active TGF-β1 instructs the differentiation of other T cell subsets, including T17 cells. Here, we will review TGF-β1 signaling in T development and function and discuss knowledge gaps, future research, and the TGF-β1/T axis in the context of cancer immunotherapy and fibrosis.
摘要
转化生长因子-β1（TGF-β1）与调节性 T 细胞（T）生物学密切相关。然而，由于这种细胞因子的多效性和上下文相关的活性以及 T 的多方面生物学特性，精确理清 TGF-β1 在 T 分化和功能中的作用变得复杂。在 CD4 T 细胞中，T 是潜伏 TGF-β1 的主要产生者，并且通过表达细胞表面对接受体糖蛋白 A 重复主要（GARP）和αv 整合素，能够独特地激活这种细胞因子。尽管大量证据表明 T 衍生的 TGF-β1 在 T 免疫抑制中没有重要作用，但 TGF-β1 信号对于 T 在胸腺和外周中的发育至关重要。此外，活性 TGF-β1 指导包括 T17 细胞在内的其他 T 细胞亚群的分化。在这里，我们将回顾 TGF-β1 信号在 T 发育和功能中的作用，并讨论知识空白、未来研究以及 TGF-β1/T 轴在癌症免疫治疗和纤维化中的作用。
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