新型抗惊厥药拉莫三嗪对癫痫患者发作间期棘波的影响。
The effect of lamotrigine, a novel anticonvulsant, on interictal spikes in patients with epilepsy.
作者信息
Jawad S, Oxley J, Yuen W C, Richens A
出版信息
Br J Clin Pharmacol. 1986 Aug;22(2):191-3. doi: 10.1111/j.1365-2125.1986.tb05249.x.
Abstract
Lamotrigine, a novel anticonvulsant, has been evaluated in patients with epilepsy using the method of interictal EEG spike counting. In a randomised double-blind trial it was found that oral lamotrigine (240 mg) was more effective than placebo, but less effective than diazepam (20 mg) in suppressing interictal spikes. Further clinical evaluation of lamotrigine is recommended in patients with epilepsy.
摘要
拉莫三嗪是一种新型抗惊厥药，已采用发作间期脑电图棘波计数法在癫痫患者中进行了评估。在一项随机双盲试验中发现，口服拉莫三嗪（240毫克）在抑制发作间期棘波方面比安慰剂更有效，但比地西泮（20毫克）效果差。建议对癫痫患者进一步进行拉莫三嗪的临床评估。
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