State Key Laboratory of Trauma, Burn and Combined Injury, Institute of Burn Research, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China.
J Burn Care Res. 2022 Nov 2;43(6):1351-1357. doi: 10.1093/jbcr/irac037.
The aim is to examine the prognostic value of N-terminal pro-brain natriuretic peptide (NT-proBNP) in patients with major burns and sepsis. We collected the data of major burn patients who were admitted to our department. We compared the age, sex, burn area, burn depth, length of hospitalization, and mortality rate between the sepsis group and non-sepsis group and compared NT-proBNP, procalcitonin (PCT), platelet count, Sequential Organ Failure Assessment (SOFA) score, and quick SOFA (qSOFA) score between the survivors and nonsurvivors in the sepsis group. Receiver operating characteristic (ROC) curves were used in sepsis patients to evaluate the prognostic value of NT-proBNP, PCT, SOFA score, qSOFA score, etc. Kaplan-Meier survival curves were used to compare the 90-day survival curves of patients. Logistic regression analysis was used to analyze the risk factors that affect the prognosis of sepsis patients. There were 90 major burn patients with sepsis and 114 major burn patients without sepsis. The mortality rate for the major burn sepsis group was significantly higher than that for the non-sepsis group. The NT-proBNP level in sepsis patients in the nonsurvivor group was 2900 pg/ml, which was significantly higher than that in patients in the survivor group. Survival analysis showed that the mean survival time for the NT-proBNP >2000 pg/ml group was 15.08 days. Multivariate regression analysis indicated that NT-proBNP was an independent risk factor for mortality in burn patients with sepsis. NT-proBNP can be used as a prognostic marker in patients with major burns and sepsis.
目的是探讨脑钠肽前体（NT-proBNP）在大面积烧伤合并脓毒症患者中的预后价值。我们收集了我院收治的大面积烧伤患者的数据。我们比较了脓毒症组和非脓毒症组患者的年龄、性别、烧伤面积、烧伤深度、住院时间和死亡率，比较了脓毒症组存活者和死亡者的 NT-proBNP、降钙素原（PCT）、血小板计数、序贯器官衰竭评估（SOFA）评分和快速 SOFA（qSOFA）评分。采用受试者工作特征（ROC）曲线评估 NT-proBNP、PCT、SOFA 评分、qSOFA 评分等对脓毒症患者预后的预测价值。Kaplan-Meier 生存曲线比较了患者的 90 天生存曲线。采用 logistic 回归分析分析影响脓毒症患者预后的危险因素。共有 90 例大面积烧伤合并脓毒症患者和 114 例大面积烧伤无脓毒症患者。大面积烧伤脓毒症组的死亡率明显高于非脓毒症组。脓毒症患者死亡组的 NT-proBNP 水平为 2900pg/ml，明显高于存活组。生存分析显示，NT-proBNP >2000pg/ml 组的平均生存时间为 15.08 天。多变量回归分析表明，NT-proBNP 是烧伤合并脓毒症患者死亡的独立危险因素。NT-proBNP 可作为大面积烧伤合并脓毒症患者的预后标志物。
