NHC Key Laboratory of Drug Addiction Medicine, Kunming Medical University, Kunming 650032, China; Scientific Research Laboratory Center, First Affiliated Hospital of Kunming Medical University, Kunming 650032, China.
NHC Key Laboratory of Drug Addiction Medicine, Kunming Medical University, Kunming 650032, China; Department of Gastrointestinal and Hernia Surgery, First Affiliated Hospital of Kunming Medical University, Kunming 650032, China.
Int Immunopharmacol. 2022 Jun;107:108696. doi: 10.1016/j.intimp.2022.108696. Epub 2022 Mar 15.
Drug withdrawal elicits immune responses that contribute to the development of withdrawal symptoms and relapse. The understanding of the immunologic dynamics after drug withdrawal is limited, precluding the finding of promising immune intervention measures. Here, we performed cytokine and multiplex immune profiling in heroin, methamphetamine (METH) and ephedrine users after withdrawal and identified the correlation between cytokines and other immune parameters. We showed that broad and strong inflammatory responses occurred at the early stage after drug withdrawal, and the inflammatory responses showed a downtrend with the extension of withdrawal time. Notably, immune dysregulation remained through and may last longer than 12 months after withdrawal in heroin and METH users. Our findings suggest that cytokines, immune cells, complement and immunoglobulin form a complex immune network that regulates immune responses after withdrawal. These data provide a reference for future scientific research and drug research and development.
药物戒断会引发免疫反应，这些反应有助于戒断症状和复吸的发展。目前对于药物戒断后免疫动态的了解有限，这限制了寻找有前途的免疫干预措施。在这里，我们在海洛因、冰毒和麻黄碱使用者戒断后进行细胞因子和多重免疫分析，并确定了细胞因子与其他免疫参数之间的相关性。我们表明，药物戒断后早期会发生广泛而强烈的炎症反应，并且随着戒断时间的延长，炎症反应呈下降趋势。值得注意的是，在海洛因和冰毒使用者中，免疫失调持续存在，并且可能持续 12 个月以上。我们的研究结果表明，细胞因子、免疫细胞、补体和免疫球蛋白形成了一个复杂的免疫网络，调节戒断后的免疫反应。这些数据为未来的科学研究和药物研发提供了参考。
