Huang Yuyan, Wang Weiyan, Hei Gangrui, Yang Ye, Long Yujun, Wang Xiaoyi, Xiao Jingmei, Xu Xijia, Song Xueqin, Gao Shuzhan, Shao Tiannan, Huang Jing, Wang Ying, Zhao Jingping, Wu Renrong
Department of Psychiatry, and National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan, China.
The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450000, China.
Asian J Psychiatr. 2022 May;71:103055. doi: 10.1016/j.ajp.2022.103055. Epub 2022 Mar 1.
Patients with schizophrenia consistently present pervasive cognitive deficits, but the neurobiological mechanism of cognitive impairments remains unclear. By analyzing regional homogeneity (ReHo) of resting-state functional Magnetic Resonance Imaging, this study aimed to explore the association between brain functional alterations and cognitive deficits in first-episode schizophrenia (FES) with a relatively large sample.
A total of 187 patients with FES and 100 healthy controls from 3 independent cohorts underwent resting-state functional magnetic resonance scans. The MATRICS Consensus Cognitive Battery (MCCB) was used to assess cognitive function. Partial correlation analysis was performed between abnormal ReHo values and the severity of symptoms and cognitive deficits.
Compared with healthy controls, ReHo values increased in right superior frontal cortex and decreased in right anterior cingulate cortex (ACC), left middle occipital gyrus (MOG), left cuneus, right posterior cingulate cortex (PCC), and right superior occipital gyrus in schizophrenia patients. ReHo values in ACC, PCC and superior occipital gyrus were correlated with PANSS scores. In addition, ReHo values in ACC and MOG were negatively correlated with working memory; left cuneus was positively correlated with multiple cognitive domains (speed of processing, attention/vigilance and social cognition); PCC was positively correlated with verbal learning; right superior occipital gyrus was positively correlated with speed of processing and social cognition.
In conclusion, we found widespread ReHo alterations and cognitive dysfunction in FES. And the pathophysiology mechanism of a wide range of cognitive deficits may be related to abnormal spontaneous brain activity.
精神分裂症患者始终存在普遍的认知缺陷，但认知障碍的神经生物学机制仍不清楚。通过分析静息态功能磁共振成像的局部一致性（ReHo），本研究旨在以相对大的样本量探讨首发精神分裂症（FES）患者脑功能改变与认知缺陷之间的关联。
来自3个独立队列的187例FES患者和100名健康对照者接受了静息态功能磁共振扫描。使用MATRICS共识认知成套测验（MCCB）评估认知功能。对异常ReHo值与症状严重程度和认知缺陷之间进行偏相关分析。
与健康对照相比，精神分裂症患者右侧额上回的ReHo值升高，而右侧前扣带回皮质（ACC）、左侧枕中回（MOG）、左侧楔叶、右侧后扣带回皮质（PCC）和右侧枕上回的ReHo值降低。ACC、PCC和枕上回的ReHo值与阳性和阴性症状量表（PANSS）评分相关。此外，ACC和MOG的ReHo值与工作记忆呈负相关；左侧楔叶与多个认知领域（加工速度、注意力/警觉性和社会认知）呈正相关；PCC与言语学习呈正相关；右侧枕上回与加工速度和社会认知呈正相关。
总之，我们发现FES患者存在广泛的ReHo改变和认知功能障碍。多种认知缺陷的病理生理机制可能与异常的自发脑活动有关。
